Results 131 to 140 of about 4,976,171 (334)

Underlying Mechanisms Involved in Gambling Disorder Severity: A Pathway Analysis Considering Genetic, Psychosocial, and Clinical Variables [PDF]

, 2023
Neus Solé‐Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Manel Gené, C. Barrot, Mónica Gómez‐Peña, Laura Moragas, Nicolás Ramoz, Philip Gorwood, Fernando Fernández‐Aranda, Susana Jiménez‐Múrcia   +11 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort

Nature Communications
Combining genotype and phenotype data promises to greatly increase the value of macaque as biomedical models for human disease. Here we launch the Macaque Biobank project by deeply sequencing 919 captive Chinese rhesus macaques (CRM) while assessing 52 ...
Bao-Lin Zhang, Yongxuan Chen, Yali Zhang, Yicheng Qiao, Yang Wu, Yi Zhang, Yizheng Lu, Xinran You, Yanling Li, Hong-Di Huang, Qiong Wang, Yijiang Li, Yun Wang, Wenxian Xiao, Hexian Duan, Ming-Hao Qiu, Nan-Hui Chen, Xiaomei Yu, Min-Min Yang, Longbao Lv, David N. Cooper, Ping Zheng, Yong-Gang Yao, Ning Liu, Jian-Hong Wang, Dong-Dong Wu   +25 more
doaj   +1 more source

Using SDS-PAGE and ISSR as biochemical markers for assessment the genetic similarity and protein analysis of some cyprinid fish species

, 2020
Ali H. Abu-Almaaty, Iman M. Bahgat, Zaineb M. Al-Tahr   +2 more
openalex   +2 more sources

Genetic Variability, Heritability and Genetic Advance Analysis in Segregating Population of Black Gram [Vigna mungo (L.) Hepper] [PDF]

, 2018
Rakesh Gandi, N. Shunmugavalli, Muthu swamy   +2 more
openalex   +1 more source

Evaluation of Genetic Diversity in Dog Breeds Using Pedigree and Molecular Analysis: A Review [PDF]

, 2022
Ripfumelo Success Mabunda, Mahlako L. Makgahlela, Khathutshelo Agree Nephawe, Bohani Mtileni   +3 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source