Results 291 to 300 of about 4,976,171 (334)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Clinical phenotype and molecular genetic analysis of 24 cases of Beckwith-Wiedemann syndrome. [PDF]

Transl Pediatr
Wu Z, Yin X, Li X, Mei H, Li J, Huang Z, Cheng J, Yi P, Zhang W, Xu A.   +9 more
europepmc   +1 more source

Genetic analysis of thalassemia in putian: comparative insights into mutation spectra with other global regions. [PDF]

Ann Hematol
Yu L, Xu G, Chen Z, Lin K, Li J, Lin H.
europepmc   +1 more source

Genetic Analysis Reveals a Protective Effect of Sphingomyelin on Cholelithiasis. [PDF]

Genes (Basel)
Mao K, Li A, Liu H, Gao Y, Wang Z, Wang X, Liu S, Gao Z, Quan J, Shao M, Liu Y, Shi L, Zhang B, Zhang T.   +13 more
europepmc   +1 more source

Distribution and population genetic analysis of lymnaeid snails in Aomori prefecture, Japan. [PDF]

J Vet Med Sci
Kamiharako Y, Nakayama K, Takayama Y, Ohari Y, Nakamura S, Hakozaki J, Haraguchi A, Nakanome N, Tamodding N, Wahid I, Kusakisako K, Ikadai H.   +11 more
europepmc   +1 more source

Clinical and genetic analysis of Majeed syndrome caused by LPIN2 complex heterozygous mutation and literature review. [PDF]

Front Pediatr
Wang S, Yu T, He X, Ding Y, Wu Y.
europepmc   +1 more source

Genetic analysis of congenital hemimelia in buffaloes from Southern Italy

, 2013
Simona Tafuri, Luigi Michele Pavone, D. Santoro, Sara Albarella, Silviana Rea, Valeria de Pasquale, Rossella Della Morte, V. Peretti   +7 more
openalex   +1 more source