Results 291 to 300 of about 8,691,632 (395)
The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany +9 morewiley +1 more sourceA nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun +13 morewiley +1 more sourceTherapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim +18 morewiley +1 more sourceGenome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Nature Genetics, 2019 R. Karlsson Linnér, Pietro Biroli, Edward Kong, S. Meddens, R. Wedow, M. Fontana, M. Lebreton, Stephen P. Tino, A. Abdellaoui, Anke R. Hammerschlag, M. Nivard, A. Okbay, C. A. Rietveld, P. Timshel, M. Trzaskowski, R. Vlaming, C. Zünd, Y. Bao, Laura Buzdugan, Ann H. Caplin, Chia-Yen Chen, P. Eibich, P. Fontanillas, J. González, Peter K. Joshi, V. Karhunen, A. Kleinman, R. Levin, C. Lill, Gerardus A. Meddens, G. Muntané, S. Sanchez-Roige, F. J. Rooij, E. Taskesen, Yang Wu, Futao Zhang, Michelle Babak Robert K. Katarzyna Sarah L. Nicholas A. Kar Agee Alipanahi Bell Bryc Elson Furlotte Huber Litt, M. Agee, B. Alipanahi, R. Bell, K. Bryc, S. Elson, N. Furlotte, K. Huber, N. Litterman, J. McCreight, M. Mcintyre, J. Mountain, C. Northover, S. Pitts, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, C. H. Wilson, Mawussé Habibul Isabel Anand Philip Alexis Frank Marc Dorr Agbessi Ahsan Alves Andiappan Awadalla Battle Beut, M. Agbessi, H. Ahsan, I. Alves, A. Andiappan, P. Awadalla, A. Battle, F. Beutner, Marc Jan Bonder, D. Boomsma, M. Christiansen, A. Claringbould, Patrick Deelen, T. Esko, M. Favé, L. Franke, T. Frayling, S. Gharib, G. Gibson, B. Heijmans, G. Hemani, R. Jansen, M. Kähönen, A. Kalnapenkis, S. Kasela, J. Kettunen, Yungil Kim, H. Kirsten, P. Kovacs, K. Krohn, J. Kronberg-Guzman, V. Kukushkina, Z. Kutalik, Bernett Lee, T. Lehtimäki, M. Loeffler, U. Marigorta, A. Metspalu, L. Milani, G. Montgomery, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, M. Perola, N. Pervjakova, B. Pierce, J. Powell, H. Prokisch, B. Psaty, O. Raitakari, S. Ring, S. Ripatti, Olaf Rotzchke, S. Rüeger, A. Saha, M. Scholz, K. Schramm, I. Seppälä, M. Stumvoll, P. Sullivan, P. Hoen, A. Teumer, J. Thiery, L. Tong, A. Tönjes, J. Dongen, J. Meurs, J. Verlouw, P. Visscher, U. Völker, U. Võsa, H. Westra, H. Yaghootkar, Jian Yang, B. Zeng, Aysu Jonathan P. Mark Alan James J. Tune H. Cornelius A Okbay Beauchamp Fontana Lee Pers Rietveld Turley C, A. Okbay, J. Beauchamp, James J. Lee, T. Pers, C. A. Rietveld, P. Turley, Guo-Bo Chen, V. Emilsson, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, P. Timshel, Ronald de Vlaming, T. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. Brandsma, M. P. Concas, J. Derringer, T. Galesloot, G. Girotto, Richa Gupta, Leanne M. Hall, S. Harris, E. Hofer, M. Horikoshi, J. Huffman, Kadri Kaasik, I. Kalafati, R. Karlsson, A. Kong, J. Lahti, S. J. Lee, C. D. de Leeuw, P. Lind, K. Lindgren, Tian Liu, M. Mangino, J. Marten, E. Mihailov, Michael B. Miller, P. J. Most, C. Oldmeadow, A. Payton, W. Peyrot, Yong Qian, R. Rueedi, E. Salvi, B. Schmidt, Katharina E. Schraut, Jianxin Shi, A. Smith, R. Poot, B. S. Pourcain, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, Jingyun Yang, Wei Zhao, Zhihong Zhu, B. Alizadeh, N. Amin, A. Bakshi, S. Baumeister, G. Biino, K. Bønnelykke, P. Boyle, H. Campbell, F. Cappuccio, G. Davies, J. De Neve, P. Deloukas, I. Demuth, Jun Ding, L. Eisele, N. Eklund, David M. Evans, J. Faul, M. Feitosa, A. Forstner, I. Gandin, Bjarni Gunnarsson, B. Halldórsson, T. Harris, A. Heath, L. Hocking, E. Holliday, G. Homuth, M. Horan, J. Hottenga, P. D. De Jager, A. Jugessur, M. Kaakinen, S. Kanoni, Liisa Keltigangas-Järvinen, L. Kiemeney, I. Kolčić, S. Koskinen, A. Kraja, M. Kroh, A. Latvala, L. Launer, M. Lebreton, D. Levinson, P. Lichtenstein, P. Lichtner, D. Liewald, A. Loukola, P. Madden, R. Mägi, T. Mäki-Opas, R. Marioni, P. Marques-Vidal, George Mcmahon, C. Meisinger, T. Meitinger, Y. Milaneschi, Ronny Myhre, C. Nelson, D. Nyholt, W. Ollier, A. Palotie, L. Paternoster, N. Pedersen, K. Petrovic, D. Porteous, K. Räikkönen, S. Ring, A. Robino, Olga Rostapshova, I. Rudan, A. Rustichini, V. Salomaa, A. Sanders, Antti-Pekka Sarin, H. Schmidt, R. Scott, Blair H. Smith, Jennifer A. Smith, J. Staessen, E. Steinhagen-Thiessen, K. Strauch, A. Terracciano, M. Tobin, Sheila Ulivi, S. Vaccargiu, L. Quaye, C. Venturini, Anna A. E. Vinkhuyzen, H. Völzke, J. Vonk, D. Vozzi, Johannes Waage, E. Ware, G. Willemsen, J. Attia, D. Bennett, K. Berger, L. Bertram, H. Bisgaard, I. Borecki, U. Bültmann, C. Chabris, F. Cucca, D. Cusi, I. Deary, G. Dedoussis, C. Duijn, J. Eriksson, B. Franke, P. Gasparini, P. Gejman, C. Gieger, H. Grabe, J. Gratten, P. Groenen, V. Gudnason, P. Harst, C. Hayward, D. Hinds, W. Hoffmann, E. Hyppönen, W. Iacono, B. Jacobsson, M. Järvelin, K. Jöckel, J. Kaprio, S. Kardia, Steven F. Lehrer, P. Magnusson, N. Martin, M. McGue, N. Pendleton, N. Pirastu, M. Pirastu, O. Polašek, D. Posthuma, C. Power, M. Province, N. Samani, D. Schlessinger, R. Schmidt, T. Sørensen, T. Spector, K. Stefánsson, U. Thorsteinsdóttir, A. Thurik, N. Timpson, H. Tiemeier, A. Uitterlinden, V. Vitart, P. Vollenweider, D. Weir, James F. Wilson, A. Wright, D. Conley, R. Krueger, G. Smith, A. Hofman, David Laibson, S. Medland, M. Meyer, M. Johannesson, P. Koellinger, D. Cesarini, D. Benjamin, A. Auton, J. Boardman, D. Clark, Andrew Conlin, Conora Dolan, U. Fischbacher, K. Harris, G. Hasler, M. Ikram, Sonia Jain, R. Karlsson, R. Kessler, M. Kooyman, J. Mackillop, M. Männikkö, C. Morcillo-Suarez, M. McQueen, Klaus M. Schmidt, M. Smart, Matthias Sutter, A. Thurik, Jon White, H. Wit, Jian Yang, E. Fehr, D. Hinds, M. Johannesson, M. Kumari, David Laibson, P. Magnusson, A. Navarro, A. Palmer, D. Posthuma, D. Schunk, M. Stein, R. Svento, H. Tiemeier, P. Timmers, R. Ursano, G. Wagner, James F. Wilson, James J. Lee, D. Benjamin, J. Beauchamp +406 moresemanticscholar +1 more sourceUnraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández +12 morewiley +1 more source
