Results 291 to 300 of about 2,718,862 (371)

Asymptotically exact fit for linear mixed model in genetic association studies. [PDF]

Genetics
Guan Y, Levy D.
europepmc   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease.

JAMA Netw Open
Fan J, Hao J, Fu Y, Liu X, Qu HQ, Glessner JT, Ji D, Liu W, Zheng G, Ding Z, Cui S, Xia Q, Hakonarson H, Wei W, Li J.   +14 more
europepmc   +1 more source

Genetic association mapping leveraging Gaussian processes. [PDF]

J Hum Genet
Kumasaka N.
europepmc   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

Author Correction: Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension. [PDF]

Sci Rep
Zhang SS, Larrabee L, Chang AH, Desai S, Sloan L, Wang X, Wu Y, Parvez N, Amaratunga K, Hartman AC, Whitnall A, Mason J, Barton NP, Chu AY, Davitte JM, Csakai AJ, Tibbetts CV, Tolbert AE, O'Keefe H, Polanco J, Foley J, Kmett C, Kehler J, Kozejova G, Wang F, Mayer AP, Koenig P, Foletti D, Pitts SJ, Schnackenberg CG.   +29 more
europepmc   +1 more source

MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer

Molecular Oncology, Volume 19, Issue 4, Page 1188-1202, April 2025.
Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara, Rosalia Battaglia, Angela Caponnetto, Anna Fazzio, Michele Stella, Cristina Barbagallo, Nicolò Musso, Federica Lunelio, Maria Elena Vento, Placido Borzì, Paolo Scollo, Davide Barbagallo, Marco Ragusa, Salvatore Pernagallo, Cinzia Di Pietro   +14 more
wiley   +1 more source

Genetic association of long non-coding RNA ANRIL polymorphism with the risk of type 2 diabetes mellitus in the Chinese Han population. [PDF]

Diabetol Metab Syndr
Li X, Yang A, Liu X, Zhang R, Zhou H, Xu S.   +5 more
europepmc   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, Volume 19, Issue 5, Page 1508-1516, May 2025.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Letter to the editor on "No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies". [PDF]

Sex Med
Zhu X, Zhao J, Tang M, Fu S, Zuo J, Chen J.   +5 more
europepmc   +1 more source