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RETRACTION: Identifying the Genetic Association Between Common Rheumatic Diseases and Vitiligo. [PDF]
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The Lancet, 2005
We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
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We review the rationale behind and discuss methods of design and analysis of genetic association studies. There are similarities between genetic association studies and classic epidemiological studies of environmental risk factors but there are also issues that are specific to studies of genetic risk factors such as the use of particular family-based ...
Cordell HJ, Clayton DG
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Genetic associates/counselors in genetic services
American Journal of Medical Genetics, 1980AbstractA survey of US directors of genetic services showed that about 38% of the non‐physician professionals providing such services are genetic associates/counselors (GAs). Over 90% of GAs appear to be involved in direct human services, rather than in the performance of laboratory procedures or research.Although they wanted GAs to be competent in ...
Seymour Kessler, John M. Optiz
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Biological Psychiatry, 2007
Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication.Genetically realistic simulation data of a typical genotyping/analytic ...
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Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication.Genetically realistic simulation data of a typical genotyping/analytic ...
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Genetic Variations and Association
2010Publisher Summary This chapter provides information about the human hydroxytryptamine (HT)R6 gene structure, its evolution, and its expression profile in both the brain and in peripheral tissues. The chapter describes the regulatory regions like binding sites for transcription factors (TFs) or for miRNA.
GENNARELLI, Massimo, CATTANEO, Annamaria
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2006
AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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AbstractThis chapter focuses on genetic association studies. The goal of genetic association studies is to investigate the effects of genotypic variation on disease risk. These designs are built on a concept of a genetic cause that closely resembles the concept of a risk factor in epidemiology.
Ezra Susser +3 more
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The Biomedical & Life Sciences Collection, 2009
Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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2014
In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
openaire +1 more source