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Genetics of menopause-associated diseases
Maturitas, 2001Menopause is the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. It is estimated that perhaps 50 million women worldwide will go into menopause annually. Atherosclerotic cardiovascular disease, osteoporotic fractures and Alzheimer's dementia are common chronic disorders after menopause, representing major ...
F. MASSART +2 more
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Genetic associations in diabetic nephropathy
Clinical and Experimental Nephrology, 2013Diabetic nephropathy is a complex disease, caused by both environmental and genetic factors. As in most complex diseases, genetic association studies in diabetic nephropathy showed inconsistent results. In retrospect, studies with small sample sizes, given what are now known to be small odds ratios, were partially responsible for this poor replication ...
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Genetics of Associated Syndromes
2021Congenital anomalies of the upper extremity (CAUE) are seen in a number of syndromes, either as an occasional feature or as a major or even presenting feature. In this chapter, only the syndromes in which the CAUE are defining or major features are included. For each of these syndromes, the genetic basis, including specific genes, if known, is included.
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From Genetic Association to Genetic Switch
Science, 2008Human genetic studies have led to the identification of a transcriptional regulator that could serve as a therapeutic target for adult hemoglobin disorders.
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Association Studies in Genetics
2011This chapter is devoted at first to a quick review of case control studies in genetic epidemiology. The case–control method is usually applied in genetic epidemiology to elucidate the role of genetic factors and their interaction with environmental factors in the aetiology of human diseases.
Luigi Salmaso +3 more
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Genetic Association Studies [PDF]
, 2009 Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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The Genetics of Adeno-Associated Virus
1984Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
Richard Jude Samulski +4 more
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Association genetics in crop improvement
Current Opinion in Plant Biology, 2010Increased availability of high throughput genotyping technology together with advances in DNA sequencing and in the development of statistical methodology appropriate for genome-wide association scan mapping in presence of considerable population structure contributed to the increased interest association mapping in plants. While most published studies
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2014
In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
openaire +2 more sources