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From Genetic Association to Genetic Switch
Science, 2008Human genetic studies have led to the identification of a transcriptional regulator that could serve as a therapeutic target for adult hemoglobin disorders.
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Genetic Association Studies [PDF]
, 2009 Recent technological advancements allowing for large-scale sequencing efforts present an exciting opportunity to uncover the genetic underpinnings of complex diseases. In an attempt to characterize these genetic contributors to disease, investigators have embarked in multitude on what are commonly referred to as population-based genetic association ...
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Association Studies in Genetics
2011This chapter is devoted at first to a quick review of case control studies in genetic epidemiology. The case–control method is usually applied in genetic epidemiology to elucidate the role of genetic factors and their interaction with environmental factors in the aetiology of human diseases.
Luigi Salmaso +3 more
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2014
In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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In genetic association studies, one analyzes associations between a (potentially very large) set of genetic markers and a phenotype of interest. This is a particular multiple test problem which has several challenging aspects, for instance the high dimensionality of the statistical parameter and the discreteness of the statistical model.
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Association genetics in crop improvement
Current Opinion in Plant Biology, 2010Increased availability of high throughput genotyping technology together with advances in DNA sequencing and in the development of statistical methodology appropriate for genome-wide association scan mapping in presence of considerable population structure contributed to the increased interest association mapping in plants. While most published studies
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The Genetics of Adeno-Associated Virus
1984Adeno-associated virus (AAV) is a defective parvovirus which is absolutely dependent on coinfection with a helper virus for a productive lytic cycle (for a review, see ref. 1). Either adenoviruses or herpes viruses can act as helpers (2–5) . In the absence of a helper virus, AAV efficiently integrates into host cell chromosomes via its inverted ...
Richard Jude Samulski +4 more
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Familial and Genetic Associations
1991Research with animals has indicated that there is a genetic component in the etiology of multiple myeloma (this volume). Human studies have also provided some clues to the genetic basis of the disease. Given the paucity of known environmental risk factors for multiple myeloma an understanding of the role that genetic factors may play is crucial ...
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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Nature Genetics, 2007L. Bertram +4 more
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Genetic association studies in osteoarthritis: is it fairytale?
Current Opinion in Rheumatology, 2017S. Warner, A. Valdes
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