Results 111 to 120 of about 967,622 (295)

Genetic parameters and purebred–crossbred genetic correlations for growth, meat quality, and carcass traits in pigs [PDF]

, 2020
Hadi Esfandyari, Dinesh M. Thekkoot, Robert Kemp, Graham Plastow, Jack C. M. Dekkers   +4 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically determined protein-protein networks

HGG Advances
Summary: Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two variables ...
Yi-Ting Tsai, Yana Hrytsenko, Michael Elgart, Usman A. Tahir, Zsu-Zsu Chen, James G. Wilson, Robert E. Gerszten, Tamar Sofer   +7 more
doaj   +1 more source

Additional file 2 of Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment

, 2021
Matthias Wielscher, André F.S. Amaral, Diana A. van der Plaat, Louise V. Wain, Sylvain Sebért, David Mosén-Ansorena, Juha Auvinen, Karl‐Heinz Herzig, Abbas Dehghan, Deborah Jarvis, Marjo‐Riitta Järvelin   +10 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Estimation of heritability and genetic parameters for carcass traits and primal cut production traits in Hanwoo

Journal of Animal Reproduction and Biotechnology
Background: The Hanwoo industry must develop technologies that can increase the production of preferred cuts to match changing consumer trends. In this study, we aimed to estimate the genetic parameters for carcass traits (carcass weight, eye muscle area,
Jae Don Oh, Gwang Hyeon Lee, Hong Sik Kong   +2 more
doaj   +1 more source

Evaluation of genetic variability, correlation and path analysis for yield related traits in redgram [Cajanus cajan (L.) Mill sp.] suitable for the light soils of Prakasam tract [PDF]

P. Haritha, M Triveni, P. Sandhya Rani, Ch.V. Rao, KV Siva Reddy, D. Mohan Reddy   +5 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Autosomal dominant polycystic kidney disease—type 2. Ultrasound, genetic and clinical correlations [PDF]

, 2000
Kyproulla Demetriou, Chrysa Tziakouri, Kristiana Anninou, Andri Eleftheriou, Michalis Koptides, Alexia Nicolaou, Constantinos Deltas, Alkis Pierides   +7 more
openalex   +1 more source