Results 121 to 130 of about 8,395,400 (376)

On the nature of intraspecific genetic variability: Evidence against the ruling paradigm [PDF]

open access: yesarXiv, 2011
Empirical evidence is presented which contradicts the established interpretation of the intraspecific genetic variability as the adaptive potential of the species: the uniform evolutionary tempo across the life kingdom, species discreteness, and absence of correlation between genetic variability and prosperity of extant species testify against the ...
arxiv  

Estimation of the genetic Gaussian network using GWAS summary data [PDF]

open access: yesBiometrics, Volume 80, Issue 4, December 2024, ujae148
Genetic Gaussian network of multiple phenotypes constructed through the genetic correlation matrix is informative for understanding their biological dependencies. However, its interpretation may be challenging because the estimated genetic correlations are biased due to estimation errors and horizontal pleiotropy inherent in GWAS summary statistics ...
arxiv   +1 more source

Determination of Ion Exchange Parameters by a Genetic Algorithm [PDF]

open access: yes, 2005
Modeling the process of ion exchange in glass requires accurate knowledge of the self-diffusion coefficients of the incoming and outgoing ions. Furthermore, correlating the concentration profile of the incoming ions to a change in refractive index ...
Honkanen, Seppo, West, Brian R.
core   +2 more sources

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Estudo das associações genéticas entre perímetro escrotal e características reprodutivas de fêmeas Nelore Genetic association among scrotal circumference and female reproductive traits in Nellore

open access: yesRevista Brasileira de Zootecnia, 2000
Os objetivos deste trabalho foram estimar parâmetros genéticos para as características perímetro escrotal (PE), medido aos 12 (PE12, n = 652) e 18 (PE18, n = 607) meses de idade, idade ao primeiro parto (IPP, n = 1582), datas do primeiro (DPP, n = 1582 ...
Selmos Luiz Gressler   +5 more
doaj   +1 more source

Rapid reversal of a potentially constraining genetic covariance between leaf and flower traits in Silene latifolia

open access: yesEcology and Evolution, 2020
Genetic covariance between two traits generates correlated responses to selection, and may either enhance or constrain adaptation. Silene latifolia exhibits potentially constraining genetic covariance between specific leaf area (SLA) and flower number in
Janet C. Steven   +3 more
doaj   +1 more source

On genetic correlation estimation with summary statistics from genome-wide association studies [PDF]

open access: yesarXiv, 2019
Genome-wide association studies (GWAS) have been widely used to examine the association between single nucleotide polymorphisms (SNPs) and complex traits, where both the sample size n and the number of SNPs p can be very large. Recently, cross-trait polygenic risk score (PRS) method has gained extremely popular for assessing genetic correlation of ...
arxiv  

Conditional inference in cis-Mendelian randomization using weak genetic factors [PDF]

open access: yesarXiv, 2020
Mendelian randomization is a widely-used method to estimate the unconfounded effect of an exposure on an outcome by using genetic variants as instrumental variables. Mendelian randomization analyses which use variants from a single genetic region (cis-MR) have gained popularity for being an economical way to provide supporting evidence for drug target ...
arxiv  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

An experimental test for genetic constraints in Drosophila melanogaster [PDF]

open access: yesarXiv, 2012
In addition to natural selection, adaptive evolution requires genetic variation to proceed. Yet the G-matrix may have limited 'genetic degrees of freedom', with certain combinations of trait values unavailable to evolution. Such limitations are often referred to as genetic constraints.
arxiv  

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