Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study. [PDF]
Zhu G, Tian R, Zhou D, Qin X.
europepmc +1 more source
Most autophagic cell death studies lack evidence of causality
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley +1 more source
The Causal Relationship Between Gut Microbiomes, Inflammatory Mediators, and Traumatic Brain Injury in Europeans: Evidence from Genetic Correlation and Functional Mapping Annotation Analyses. [PDF]
Song B+10 more
europepmc +1 more source
Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma+10 more
wiley +1 more source
Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study. [PDF]
Li M+7 more
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Key role for inhibins in effective T cell activation, migration and Th17 differentiation
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco+5 more
wiley +1 more source
Casual associations between brain structure and sarcopenia: A large-scale genetic correlation and mendelian randomization study. [PDF]
Yang G+6 more
europepmc +1 more source
Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study. [PDF]
Wu XP, Niu PP, Liu H.
europepmc +1 more source
Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap. [PDF]
Chatzi D+5 more
europepmc +1 more source
Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis. [PDF]
Zhou J+7 more
europepmc +1 more source