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Genetic correlates of efavirenz hypersusceptibility
AIDS, 2004Non-nucleoside reverse transcriptase inhibitor (NNRTI) hypersusceptibility is seen in approximately 30% of HIV isolates with nucleoside reverse transcriptase inhibitor (NRTI) resistance. NNRTI hypersusceptibility has been associated with improved outcomes to NNRTI-based therapy.To determine the genetic correlates of efavirenz hypersusceptibility.Paired
Ronald J. Bosch +4 more
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Inference about genetic correlations [PDF]
Behavior Genetics, 1988 In polygenic systems genetic correlations and the factors and specific genetic variances from genetic correlation matrices are often interpreted in terms of sets of genes common or specific to variables. While these inferences may indeed be true, a genetic correlation is not always sufficient evidence for the inferences.
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Phenotypic, Genetic and Environmental Correlations [PDF]
Biometrics, 1961 and in many instances the estimate of a phenotypic correlation is reported smaller in magnitude than that of the corresponding genetic correlation, e.g. with certain poultry records, in Lerner & Cruden [1948], sheep records in Morley [1951] and with certain dairy records in VanVleck [1960] and Searle [1961]. Such results may seem a little unexpected at
N. Z. Dairy, S. R. Searle
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Assortative mating and the genetic correlation
Theoretical and Applied Genetics, 1982The effect of assortative mating on the genetic correlation between traits X and Y is considered. Assortation on trait X changes the magnitude of the genetic correlation but not its sign. There are two situations depending on the signs of the correlation between mates (ρ) and of the random mating genetic correlation (θ): 1) if sign (θ) = sign (ρ), then
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A TEST OF THE HYPOTHESIS THAT CORRELATIONAL SELECTION GENERATES GENETIC CORRELATIONS
Evolution, 2012Theory predicts that correlational selection on two traits will cause the major axis of the bivariate G matrix to orient itself in the same direction as the correlational selection gradient. Two testable predictions follow from this: for a given pair of traits, (1) the sign of correlational selection gradient should be the same as that of the genetic ...
Derek A. Roff, Daphne J. Fairbairn
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1997
The last chapter examined the genetic basis of the resemblance between parents and offspring for a single trait. However, it is common experience that traits are not inherited as independent units, but that several traits tend to be associated with each other.
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The last chapter examined the genetic basis of the resemblance between parents and offspring for a single trait. However, it is common experience that traits are not inherited as independent units, but that several traits tend to be associated with each other.
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Oligodendrogliomas: clinical and genetic correlations
Current Opinion in Neurology, 2001Oligodendrogliomas, once obscure, are now recognized as a relatively common form of primary brain tumour, and are among the most chemosensitive of all solid human malignancies. New histopathological, molecular, and genetic information has, for the first time, allowed the distinction of several subtypes of human glioma with predictable biological and ...
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Genetic Correlations with Multiple Alleles
Biometrics, 1960Hogben [1932] gave the values for filial and fraternal correlations for matings involving two alleles in a panmictic population. The subject has been considered in great detail by Li [1955], but the known results are restricted to the case of two alleles. Consequently, if it is desired to compare a correlation derived from actual experimental data with
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An integrated framework for local genetic correlation analysis
Nature Genetics, 2022J. Werme +3 more
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The effects of phenotypic plasticity on genetic correlations [PDF]
Trends in Ecology & Evolution, 1991 Recent theory suggests that genetic correlations should help to predict the simultaneous response to selection of two or more traits, and much recent research has been directed towards understanding the sources of variation in genetic correlations.
Gerdien de Jong +2 more
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