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Potential bias in genetic correlations
Science, 2022Mating patterns across two traits can inflate estimates of genetic ...
Andrew D, Grotzinger, Matthew C, Keller
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Are Genetic Correlations and Environmental Correlations Correlated?
Nature, 1970CORRELATIONS between different characters measured on individuals of a population have both genetic and environmental causes. In an extensive genetic analysis of the open-field behaviour of mice, which is a widely used index of “emotionality”, we have found that genetic and corresponding environmental patterns of association among pairs of characters ...
Hegmann, J P, Fries, J C
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Genetic correlation in otosclerosis
American Journal of Otolaryngology, 1999The aim of this study was to determine the relationship of HLA typing in patients with otosclerosis.We used a prospective study in which HLA typing of 100 surgically confirmed otosclerosis patients were compared with age and sex matched normal individuals.HLA-A3, HLA-A9, HLA-A11, and HLA-B13 were found to be significantly higher (P < .05, .01, and .01,
S K, Singhal +4 more
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Inference About Genetic Correlations
Behavior Genetics, 1988In polygenic systems genetic correlations and the factors and specific genetic variances from genetic correlation matrices are often interpreted in terms of sets of genes common or specific to variables. While these inferences may indeed be true, a genetic correlation is not always sufficient evidence for the inferences.
Gregory Carey, G Carey
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Estimating genetic correlations
Annals of Human Genetics, 1980A method is proposed for simultaneous estimation of genetical variance and covariance components for quantitative characters and hence correlations and cross-correlations between relatives. It proceeds by successive approximations, which are not difficult to compute. Judging by examples, they appear to converge rapidly in practice.
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Genetic correlations in validating emotionality
Behavior Genetics, 1990Sixty-six rats of seven inbred strains were observed in an open field (OF) and in a light-dark preference box (LDB). Each set of apparatus provides measures of locomotor activity and of the time spent in the "most protected" area (the corners in the OF, the dark compartment in the LDB). These measures are proposed to be indices of emotionality.
F J, van der Staay +2 more
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Genetic Correlations, Tradeoffs and Environmental Variation [PDF]
Heredity, 2004 Negative genetic correlations among traits are often used as evidence for tradeoffs that can influence evolutionary trajectories in populations. While there may be evidence for negative correlations within a particular environment, genetic correlations can shift when populations encounter different environmental conditions.
Ary Hoffmann
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Genetic Correlations of Polygenic Disease Traits: From Theory to Practice
Nature Reviews Genetics, 2019 The genetic correlation describes the genetic relationship between two traits and can contribute to a better understanding of the shared biological pathways and/or the causality relationships between them. The rarity of large family cohorts with recorded
Naomi R. Wray +2 more
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Genetic correlates of insight in schizophrenia
Schizophrenia Research, 2018Insight in schizophrenia is clinically important as it is associated with several adverse outcomes. Genetic contributions to insight are unknown. We examined genetic contributions to insight by investigating if polygenic risk scores (PRS) and candidate regions were associated with insight.Schizophrenia case-only analysis of the Clinical Antipsychotics ...
Rose Mary Xavier +3 more
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Genetic correlates of efavirenz hypersusceptibility
AIDS, 2004Non-nucleoside reverse transcriptase inhibitor (NNRTI) hypersusceptibility is seen in approximately 30% of HIV isolates with nucleoside reverse transcriptase inhibitor (NRTI) resistance. NNRTI hypersusceptibility has been associated with improved outcomes to NNRTI-based therapy.To determine the genetic correlates of efavirenz hypersusceptibility.Paired
Nancy S, Shulman +4 more
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