Results 271 to 280 of about 639,109 (351)

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

open access: yesCancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

Unmasking inborn errors of immunity: identifying the red flags of immune dysregulation. [PDF]

open access: yesFront Immunol
Cortesi M   +5 more
europepmc   +1 more source

Discovering Severe Adverse Reactions From Pharmacokinetic Drug–Drug Interactions Through Literature Analysis and Electronic Health Record Verification

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 4, Page 1078-1087, April 2025.
While drug–drug interactions (DDIs) and their pharmacokinetic (PK) mechanisms are well‐studied prior to drug approval, severe adverse drug reactions (SADRs) caused by DDIs often remain underrecognized due to limitations in pre‐marketing clinical trials.
Eugene Jeong, Yu Su, Lang Li, You Chen
wiley   +1 more source

Investigating Chromosomal Radiosensitivity in Inborn Errors of Immunity: Insights from DNA Repair Disorders and Beyond. [PDF]

open access: yesJ Clin Immunol
Beyls E   +13 more
europepmc   +1 more source

Japan's Conditional/Time‐Limited Early Approval System in Regenerative Medicine: A Case Study of Rise and Falls of Autologous Skeletal Myoblast Sheets

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1171-1174, May 2025.
Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya   +3 more
wiley   +1 more source

Mental Health Across the Metabolic Spectrum. [PDF]

open access: yesBiol Psychiatry Glob Open Sci
Saxena V, Marin-Valencia I.
europepmc   +1 more source

Nerve growth factor (NGF) [PDF]

open access: yes, 1989
Azzi, Angelo   +6 more
core  

Model‐Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1413-1426, May 2025.
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ and transplantation‐related factors, associated with poor prognoses for poor graft function (PGF) and isolated thrombocytopenia.
Katharina M. Götz   +23 more
wiley   +1 more source

Fetal Hydrops: Genetic Dissection of an Unspecific Sonographic Finding-A Comprehensive Review. [PDF]

open access: yesDiagnostics (Basel)
Mastromoro G   +4 more
europepmc   +1 more source

Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population‐Based Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir   +4 more
wiley   +1 more source

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