Results 271 to 280 of about 639,109 (351)
Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley +1 more source
Unmasking inborn errors of immunity: identifying the red flags of immune dysregulation. [PDF]
Cortesi M+5 more
europepmc +1 more source
While drug–drug interactions (DDIs) and their pharmacokinetic (PK) mechanisms are well‐studied prior to drug approval, severe adverse drug reactions (SADRs) caused by DDIs often remain underrecognized due to limitations in pre‐marketing clinical trials.
Eugene Jeong, Yu Su, Lang Li, You Chen
wiley +1 more source
Investigating Chromosomal Radiosensitivity in Inborn Errors of Immunity: Insights from DNA Repair Disorders and Beyond. [PDF]
Beyls E+13 more
europepmc +1 more source
Japan's conditional/time‐limited early approval program, initiated in 2014, aimed to advance regenerative medicine by expediting market access. However, the withdrawal of autologous skeletal myoblast sheets (Heartsheet) due to ineffectiveness raises concerns about the balance between rapid approval and scientific integrity.
Hayase Hakariya+3 more
wiley +1 more source
Mental Health Across the Metabolic Spectrum. [PDF]
Saxena V, Marin-Valencia I.
europepmc +1 more source
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ and transplantation‐related factors, associated with poor prognoses for poor graft function (PGF) and isolated thrombocytopenia.
Katharina M. Götz+23 more
wiley +1 more source
Fetal Hydrops: Genetic Dissection of an Unspecific Sonographic Finding-A Comprehensive Review. [PDF]
Mastromoro G+4 more
europepmc +1 more source
Over 10 million children in the world have epilepsy, with an unknown cause in half of the cases. The gut microbiome has been associated with various neurological disorders, and certain drugs greatly disturb the microbiome. Our aim was to study the association of prenatal and childhood exposure (before the age of two) to antibiotics, proton pump ...
Unnur Gudnadottir+4 more
wiley +1 more source