Results 161 to 170 of about 851,546 (305)

Strategies to develop oil palm clones for Latin American and Africa [PDF]

, 2010
Amblard, Philippe, Cochard, Benoît, De Franqueville, Hubert, Durand-Gasselin, Tristan, Labeyrie, Axel, Nouy, Bruno, Potier, Françoise   +6 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

First review of chronic granulomatous disease in Palestine: clinical and genetic characteristics. [PDF]

Front Immunol
Thawabteh FA, Abu Rmilah S, Siaj A, Abu Khdair R, Adwan R.   +4 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Brain patterns linked to neuropsychiatric genetic risk mirror those seen in disease. [PDF]

Imaging Neurosci (Camb)
Chou CJ, Del Re EC, Wang H, Hamada K, Tian X, Iakunchykova O, Wang Y, Fiecas M, Chen CH.   +8 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Genetic aetiology of global developmental delay and intellectual disability in Africa: a scoping review. [PDF]

Front Genet
Dukuze N, Hitayezu J, Uyisenga JP, Hakizimana O, Bours V, Uwineza A, Alagbonsi AI.   +6 more
europepmc   +1 more source

MCV/Q, Medical College of Virginia Quarterly, Vol. 13 No. 4 [PDF]

, 1977

core   +1 more source

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock [PDF]

, 2009
Adzhubei, Ait-Ali, Al-Haddawi, Asif, Atapattu, Bacon, Bacon, Bakker, Barillet, Barrow, Barrow, Bishop, Boyd, Briles, Brisbin, Bumstead, Bumstead, Bumstead, Bumstead, Bumstead, Callaway, Cao, Carlén, Caverly, Cheng, Chiodini, Cole, Cutlip, Dassanayake, Davies, Diez-Tascon, Dileepan, Dominik, E. Giuffra, Ewart, Flori, Fragkou, Friars, G. Davies, Gasbarre, Gauly, Gavora, Gibbons, Gonda, Gonda, Gordon, Gougoulis, Guy, Gyles, Haesebrouck, Hala, Halbur, Hassan, Hayes, Heringstad, Hickford, Houston, Hu, Jackwood, Jensen, Jiao, Juul-Madsen, Kaiser, Kaufman, Keane, Khatkar, Koets, Kramer, Lamont, Lavi, Legarra, Lewis, Liu, Liu, Longenecker, Lund, Lundeheim, Lundeheim, MacKinnon, Mackintosh, Malek, Mariani, Martin, Mavrogianni, Mays, Meijerink, Minion, Mirsky, Moen, Mortensen, Muggli-Cockett, Nakajima, Nieuwhof, Niewold, Noormohammadi, Opriessnig, Peng, Permin, Perry, Petry, Petry, Pinard-van der Laan, Pinard-van der Laan, Purchase, Python, Raadsma, Reiner, Rise, Roehrig, Ruiz, Rupp, S. Genini, S.C. Bishop, Sacco, Schmidt, Schou, Sellwood, Smith, Snowder, Snowder, Sonstegard, Tilquin, Tsai, Tuggle, Uthe, Uthe, Vallejo, Van Diemen, Van Dorp, Van Hemert, Van Hemert, Van Reeth, Vincent, Vincent, Von Schalburg, Vögeli, Wang, Wetten, Williams, Williams, Witter, Yonash, Yonash, Yoo, Young, Yunis, Zhang, Zhu   +147 more
core   +1 more source