Results 91 to 100 of about 11,828,008 (230)
CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling
Human Genetics, 2016 The next-generation sequencing identifies a growing number of candidate genes associated with human genetic diseases, which inevitably requires efficient methods to validate the causal links between genotype and phenotype.
Jiaqi Liu +7 more
semanticscholar +1 more source
Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]
, 2008 Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos +11 more
core +1 more source
microRNAs and genetic diseases [PDF]
, 2009 microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from double-stranded hairpin precursors. They negatively regulate gene expression in animals, by binding, with imperfect base pairing, to target sites in messenger RNAs (
Banfi, Sandro +2 more
core +2 more sources
Quality in SportGaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the GBA1 gene, which encodes the enzyme glucocerebrosidase.
Alicja Kotula +8 more
doaj +1 more source
Genome-wide Causation Studies of Complex Diseases [PDF]
arXiv, 2019 Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), the signals identified by association analysis may not have specific pathological relevance to diseases so that a large fraction of disease causing genetic variants is still hidden. Association is used to measure dependence
arxiv
Mapping the Genetic-Imaging-Clinical Pathway with Applications to Alzheimer's Disease [PDF]
arXiv, 2020 Alzheimer's disease is a progressive form of dementia that results in problems with memory, thinking, and behavior. It often starts with abnormal aggregation and deposition of beta amyloid and tau, followed by neuronal damage such as atrophy of the hippocampi, leading to Alzheimer's Disease (AD).
arxiv
CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases
OncoTarget, 2016 Cancer is caused by a series of alterations in genome and epigenome mostly resulting in activation of oncogenes or inactivation of cancer suppressor genes.
F. A. Khan +8 more
semanticscholar +1 more source
Insects, 2018 Mosquitoes live under the endless threat of infections from different kinds of pathogens such as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical and physiological barriers that resist the entry of the pathogen and
Ankit Kumar +6 more
doaj +1 more source
Histopathology of the gut in rheumatic diseases [PDF]
, 2018 The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F. +4 more
core +1 more source
Journal of Education and Health PromotionBACKGROUND: A newborn with an untreatable genetic disorder could disrupt a family and affect parents’ mental health, psycho-social interaction, and parent–child relationships.
Marzyeh Kermanian +3 more
doaj +1 more source