Results 121 to 130 of about 1,395,753 (295)

Genetic epidemiology approach to estimating birth incidence and current disease prevalence for rhizomelic chondrodysplasia punctata [PDF]

, 2021
Tarik Luisman, Tara Smith, Shawn Ritchie, Karen E. Malone   +3 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies

Pharmacology Research & Perspectives
Cerebral cavernous malformation (CCM) has variable clinical symptoms, including potentially fatal hemorrhagic stroke. Treatment options are very limited, presenting a large unmet need.
Ron Alfa, Timothy Considine, Shafique Virani, Matt Pfeiffer, Anthony Donato, Daniel Dickerson, Diana Shuster, Joel Ellis, Kristen Rushton, Helen Wei, Christopher Gibson   +10 more
doaj   +1 more source

MOLECULAR GENETIC STUDIES OF NEURODEGENERATIVE DISEASE

, 2013
Tim Cooke, CB Carroll, JP Zajicek, Sian Ellard, KE Morrison   +4 more
openalex   +2 more sources

P-214 Determining the Role of TCF-4 in the Genetic Susceptibility of Crohn’s Disease of the Pouch [PDF]

, 2013
Brian Lewis, Elaine Queener, Bo Shen
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Clinical characteristic and genetic polymorphism of hereditary kidney disease. Communication 1

, 2013
М.О. Ryznychuk, V. P. Pishak
openalex   +2 more sources

Genetic Variability of Tumor Necrosis Factor Receptors Type I and II in Lymphoproliferative Diseases in the Serbian Population – [PDF]

, 2017
Tatjana Jevtović−Stoimenov, Danica Marković, Milena Despotović, Dušica Pavlović, Gordana Kocić   +4 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Systems genetic dissection of Alzheimer’s disease brain gene expression networks [PDF]

Pinghan Zhao, Omar El Fadel, Anh‐Tuan Le, Carl Grant Mangleburg, Timothy Wu, Justin Dhindsa, Bismark K Amoh, Aditi Sai Marella, Yarong Li, Nicholas T. Seyfried, Allan I. Levey, Zhandong Liu, Ismael Al‐Ramahi, Juan Botas, Joshua M. Shulman   +14 more
openalex   +1 more source