CONNECTION BETWEEN EPILEPSY AND AUTISM SPECTRUM DISORDER
Эпилепсия и пароксизмальные состояния, 2017 The role of epilepsy in developing autism spectrum disorders (ASD) is not well understood. According to some reports, epilepsy of early childhood is often found in patients with autism of early childhood.
N. N. Maslova +3 more
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Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study [PDF]
, 2010 Christine Iannaccone +8 more
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By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Growth disorders caused by variants in epigenetic regulators: progress and prospects
Frontiers in EndocrinologyEpigenetic modifications play an important role in regulation of transcription and gene expression. The molecular machinery governing epigenetic modifications, also known as epigenetic regulators, include non-coding RNA, chromatin remodelers, and enzymes
Julian C. Lui
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Impact of Tat Genetic Variation on HIV-1 Disease [PDF]
, 2012 Luna Li +7 more
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Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response. [PDF]
, 2015 Protein misfolding neurodegenerative diseases arise through neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer's disease, Huntington's disease, Parkinson's disease, motor neuron disease, tauopathies and prion ...
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
« À mains raccourcies » ou l’histoire de l’hémochromatose
UISPP JournalL’auteur se propose ici de faire le point sur l’histoire de l’hémochromatose, l’une des plus importantes maladies d’origine génétique actuelles. A partir d’exemples récents et de l’étude de deux cas personnels, l’analyse historique de l’hémochromatose ...
Jean Zammit
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DYSTROPHIC EPIDERMOLYSIS BULLOSA: CASE SERIES OF THREE RELATED PATIENTS
Central Asian Journal of Medical Hypotheses and EthicsBackground: Dystrophic Epidermolysis Bullosa (DEB) is a rare inherited skin disorder characterized by blistering, chronic wounds, and scarring due to mutations in the COL7A1 gene. While epidemiological data are available from certain regions, information
Ulpan Zharylkap +2 more
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