Results 121 to 130 of about 5,372,923 (315)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Growth disorders caused by variants in epigenetic regulators: progress and prospects

Frontiers in Endocrinology
Epigenetic modifications play an important role in regulation of transcription and gene expression. The molecular machinery governing epigenetic modifications, also known as epigenetic regulators, include non-coding RNA, chromatin remodelers, and enzymes
Julian C. Lui
doaj   +1 more source

Role of genomic typing in taxonomy, evolutionary genetics, and microbial epidemiology. [PDF]

, 2001
Currently, genetic typing of microorganisms is widely used in several major fields of microbiological research. Taxonomy, research aimed at elucidation of evolutionary dynamics or phylogenetic relationships, population ...
Struelens, M., Michel Tibayrenc, Verburgh, H., Verbrugh, H.A. (Henri), Belkum, A., van, Belkum, A.F. (Alex) van, Tibayrench, M., Arjan de Visser, Visser, J.A.G.M., de, Henri Verbrugh, Visser, A. (Arjan) de, de Visser, J.A.G.M., van Belkum, A., Marc Struelens, Tibayrenc., M., Alex van Belkum, Tibayrenc, M, Struelens, MJ, Belkum, Alex, de Visser, A, Verbrugh, Henri   +20 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Genetic Animal Models of Cardiovascular Pathologies

This review critically examines the evolving landscape of genetic animal models for investigating cardiovascular diseases (CVDs). We analyze established models, including spontaneously hypertensive rats, Watanabe hyperlipidemic rabbits, etc., and ...
Yulia Silaeva, Andrey Mozhaev, Sergei Syatkin, Vsevolod Belousov, Mikhail Blagonravov, Anna Ryabinina, Vera Ovechkina, Enzo Agostinelli, Ruslan Karpov, Maxim Filatov   +9 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Specificity of mRNA binding to proteins within the NMD machinery is influenced in cancer

Frontiers in Molecular Biosciences
IntroductionThe nonsense-mediated mRNA decay (NMD) process is recognized as the quality control of mRNAs to maintain their integrity and production of functional proteins.
Umesh Kalathiya, Monikaben Padariya
doaj   +1 more source

CONNECTION BETWEEN EPILEPSY AND AUTISM SPECTRUM DISORDER

Эпилепсия и пароксизмальные состояния, 2017
The role of epilepsy in developing autism spectrum disorders (ASD) is not well understood. According to some reports, epilepsy of early childhood is often found in patients with autism of early childhood.
N. N. Maslova, V. A. Skorobogatova, N. V. Yur’eva, N. E. Maslov   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

DYSTROPHIC EPIDERMOLYSIS BULLOSA: CASE SERIES OF THREE RELATED PATIENTS

Central Asian Journal of Medical Hypotheses and Ethics
Background: Dystrophic Epidermolysis Bullosa (DEB) is a rare inherited skin disorder characterized by blistering, chronic wounds, and scarring due to mutations in the COL7A1 gene. While epidemiological data are available from certain regions, information
Ulpan Zharylkap, Sanimbala Ospanova, Aigerim Idrissova   +2 more
doaj   +1 more source