Results 171 to 180 of about 1,395,753 (295)

Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease [PDF]

Gabriel Chew, Aaron Shengting, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, Eng‐King Tan   +7 more
openalex   +1 more source

Genetic dissection of glutathione S-transferase omega-1: identification of novel downstream targets and Alzheimer’s disease pathways

, 2022
Gang Chen, Ying Chen, Yue Jia, Meng-Die Gao, Yunfang Liu, Lu Lu   +5 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Genetic diseases underlying a spectrum of fetal effusions. [PDF]

Am J Obstet Gynecol
Gulrajani NB, Lianoglou BR, Tick K, Sahin-Hodoglugil NN, Hodoglugil U, Devine P, Van Ziffle J, Norton ME, Sparks TN.   +8 more
europepmc   +1 more source

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

, 2009
Eng‐King Tan, Chin-Song Lu, Rong Peng, Yik Ying Teo, Yah-Huei Wu-Chou, R.‐S. Chen, Yi‐Hsin Weng, C.M. Chen, Hon‐Chung Fung, Louis C.S. Tan, Z.J. Zhang, Xingkai An, G.-J. Lee-Chen, M.C. Lee, Stephanie Fook‐Chong, Jean‐Marc Burgunder, Ruey‐Meei Wu, Yih‐Ru Wu   +17 more
openalex   +2 more sources

A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation

, 2023
Lisa van Pul, Irma Maurer, Brigitte Boeser‐Nunnink, Agnes M. Harskamp, Karel A. van Dort, Neeltje A. Kootstra   +5 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Biomedical applications of organoids in genetic diseases. [PDF]

Med Rev (2021)
Huang W, Jeong S, Kim W, Chen L.
europepmc   +1 more source

Identifying Families with Likely Genetic Protective Factors against Alzheimer Disease [PDF]

, 1999
Jeremy Silverman, Christopher J. Smith, Deborah B. Marin, Sandra Birstein, Marlene Mare, Richard C. Mohs, Kenneth L. Davis   +6 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source