Results 201 to 210 of about 2,431,050 (332)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Genetic diseases underlying a spectrum of fetal effusions. [PDF]

Am J Obstet Gynecol
Gulrajani NB, Lianoglou BR, Tick K, Sahin-Hodoglugil NN, Hodoglugil U, Devine P, Van Ziffle J, Norton ME, Sparks TN.   +8 more
europepmc   +1 more source

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

, 2015
Javier Gutierrez‐Achury, Alexandra Zhernakova, Sara L. Pulit, Gosia Trynka, Karen A. Hunt, Jihane Romanos, Soumya Raychaudhuri, David A. van Heel, Cisca Wijmenga, Paul I. W. de Bakker   +9 more
openalex   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Biomedical applications of organoids in genetic diseases. [PDF]

Med Rev (2021)
Huang W, Jeong S, Kim W, Chen L.
europepmc   +1 more source

Genetic complexity in sickle cell disease

, 2008
Douglas R. Higgs, W. G. Wood
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Few shot learning for phenotype-driven diagnosis of patients with rare genetic diseases. [PDF]

NPJ Digit Med
Alsentzer E, Li MM, Kobren SN, Noori A, Undiagnosed Diseases Network, Kohane IS, Zitnik M.   +6 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Alzheimer’s Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer’s Disease

, 2022
Pavel P. Kuksa, Chia‐Lun Liu, Wei Fu, Liming Qu, Yi Zhao, Živadin Katanić, Kaylyn Clark, Amanda B Kuzma, Pei‐Chuan Ho, Kai‐Teh Tzeng, Otto Valladares, Shin‐Yi Chou, Adam C. Naj, Gerard D. Schellenberg, Li‐San Wang, Yuk Yee Leung   +15 more
openalex   +2 more sources