Results 211 to 220 of about 2,431,050 (332)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Gene therapy for genetic diseases: challenges and future directions. [PDF]

MedComm (2020)
Qie B, Tuo J, Chen F, Ding H, Lyu L.
europepmc   +1 more source

Advance in Genomics of Rare Genetic Diseases. [PDF]

Biomolecules, 2023
Sommariva E, Bellin M, Di Resta C.
europepmc   +1 more source

Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns

Fu Ting, Yiqun Yang, Chang-Hua Tang, Pei He, Shu‐Feng Lei   +4 more
openalex   +2 more sources

Association of Pyoderma Gangrenosum, Acne, and Suppurative Hidradenitis (PASH) Shares Genetic and Cytokine Profiles With Other Autoinflammatory Diseases

, 2015

openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An explainable dataset linking facial phenotypes and genes to rare genetic diseases. [PDF]

Sci Data
Song J, He M, Ren S, Shen B.
europepmc   +1 more source

RNA therapy is shining for genetic diseases. [PDF]

Mol Ther Nucleic Acids, 2023
Zheng ZM.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Next-generation sequencing (NGS) techniques for pre-symptomatic identification of genetic diseases in newborns. [PDF]

Cochrane Database Syst Rev
Pessano S, Boldor M, Faravelli F, Fiander M, Jørgensen KJ, Soll RF, Bruschettini M.   +6 more
europepmc   +1 more source