Results 221 to 230 of about 13,340,828 (402)

Diagnóstico y prevención de enfermedades genéticas. Análisis de seis años del municipio Sandino Diagnostic and prevention of the genetic diseases. Analysis of six years of the municipality Sandino

Revista de Ciencias Médicas de Pinar del Río, 2008
Introducción: En los últimos años ha aumentado la importancia de las anomalías congénitas y enfermedades hereditarias como causa de muerte en el primer año de vida.
Pedro Antonio Ramírez Sosa, Carlos Otaño Plasencia, Yusimí Martínez Fernández, Yarelis Prieto Hernández   +3 more
doaj  

Some Epidemiological and Genetic Aspects of Congenital Heart Diseases [PDF]

, 1975
N. Freire‐Maia
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Genetic Counselling in X-Linked Eye Diseases [PDF]

, 1973
J. François, Matton-Van Leuven, D. Vandenbulcke-Donck, S. De Bie   +3 more
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination

, 1975
J. S. Mackenzie, W. R. Slade, J. R. Lake, R. A. J. Priston, J. Bisby, Steven T. Laing, John W. Newman   +6 more
openalex   +1 more source

Death Discordant Twins. A New Method to Evaluate Genetic Factors in Chronic Diseases [PDF]

, 1974
Ulf dé Fairé, T Lundman
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Editorial - Patient perspectives on new therapies for genetic diseases. [PDF]

Med Genet
Elbracht M, Zweier C, Krey-Grauert I.
europepmc   +1 more source