Results 231 to 240 of about 13,340,828 (402)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Gene Dosage Sensitivity and Human Genetic Diseases. [PDF]

J Inherit Metab Dis
Veitia RA, Zschocke J, Birchler JA.
europepmc   +1 more source

An Epidemiological and Genetic Study on Registered Diseases in Finnish Ayrshire Cattle [PDF]

, 1986
Yrjo T. Gröhn, Hannu Saloniemi, Jouko Syväjärvi   +2 more
openalex   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Therapeutic Application of mRNA for Genetic Diseases. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Schürmann PJL, van Breda Vriesman SPE, Castro-Alpízar JA, Kooijmans SAA, Nieuwenhuis EES, Schiffelers RM, Fuchs SA.   +6 more
europepmc   +1 more source

Ethical, Legal, and Social Issues in Genetic Testing for Complex Genetic Diseases [PDF]

, 2011
Andrews, Lori, Zuiker, Erin Shaugnessy
core   +2 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Genetic Diseases of Fucosylation: Insights from Model Organisms. [PDF]

Genes (Basel)
Ameen MT, French CR.
europepmc   +1 more source

Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease [PDF]

, 1986
H Kamesaki, S Fukuhara, E Tatsumi, Haruto Uchino, H Yamabe, H Miwa, S Shirakawa, Masakazu Hatanaka, T Honjo   +8 more
openalex   +1 more source

Consanguinity and genetic diseases among the Bedouin population in the Negev

Journal of Community Genetics, 2019
Sarah Singer, N. Davidovitch, Yasmeen Abu Fraiha, N. Abu Freha   +3 more
semanticscholar   +1 more source