Results 231 to 240 of about 1,280,706 (342)

Genetic Diseases of Mucopolysaccharide Catabolism; Single-Enzyme Deficiency Disorders

, 1977
Elizabeth F. Neufeld
openalex   +2 more sources

Genetic Eye Disease: Retinitis Pigmentosa and Other Inherited Eye Diseases [PDF]

, 1984
B. Jay
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A framework for N-of-1 trials of individualized gene-targeted therapies for genetic diseases. [PDF]

Nat Commun
Kim-McManus O, Gleeson JG, Mignon L, Smith Fine A, Yan W, Nolen N, Demarest S, Berry-Kravis E, Finkel R, Leonard S, Finlayson S, Augustine E, Lyon GJ, Schule R, Yu T.   +14 more
europepmc   +1 more source

URIDINE MONOPHOSPHATE KINASE (UMPK)-A NEW GENETIC MARKER FOR SUSCEPTIBILITY TO HAEMOPHILUS INFLUENZAE TYPE B (HIB) DISEASE [PDF]

, 1984
Gloria M. Petersen, Diana R. Silimperi, E.M. Scott, D L Hall, Jerome I. Rotter, Joel I. Ward   +5 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Case series of kidney transplantation in two pediatric recipients with rare genetic diseases and intellectual disability. [PDF]

BMC Pediatr
Mata M, Tabbara MM, Alvarez A, Chandar J, Defreitas M, Ciancio G.   +5 more
europepmc   +1 more source

Low incidence of acute graft-versus-host disease by the administration of methotrexate and cyclosporine in Japanese leukemia patients after bone marrow transplantation from human leukocyte antigen compatible siblings; possible role of genetic homogeneity. The Nagoya Bone Marrow Transplantation Group

, 1989
Y Morishima, Y Morishita, Masashi Tanimoto, R Ohno, Hajime Saito, Keizo Horibe, Nobuyuki Hamajima, Kensuke Naito, K Yamada, S Yokomaku   +9 more
openalex   +1 more source

Vaccines '88: New Chemicals and Genetic Approaches to Vaccination. Prevention of AIDS and other viral, bacterial and parasitic diseases. Edited by H. Ginsberg, F. Brown, R. A. Lerner and R. M. Channock. New York: Cold Spring Harbor Labortory. 1988. 396 pages. Paper $9500. ISBN 0 87969 210 X. [PDF]

, 1989
Robert G. Ridley
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source