Results 241 to 250 of about 2,431,050 (332)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Additional file 1 of 3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility

Trang, Khanh B., Sharma, Prabhat, Cook, Laura, Mount, Zachary, Thomas, Rajan M., Kulkarni, Nikhil N., Cabrera, Emylette Cruz, Rachimi, Suzanna, Pahl, Matthew C., Pippin, James A., Su, Chun, Kaestner, Klaus H., O’Brien, Joan M., Wagley, Yadav, Hankenson, Kurt D., Jermusyk, Ashley, Hoskins, Jason W., Amundadottir, Laufey T., Xu, Mai, Brown, Kevin M., Anderson, Stewart A., Yang, Wenli, Titchenell, Paul M., Seale, Patrick, Zemel, Babette S., Chesi, Alessandra, Romberg, Neil, Levings, Megan K., Grant, Struan F. A., Wells, Andrew D.   +29 more
openalex   +1 more source

GENETIC ASPECTS OF ATRIAL FIBRILLATION ON THE BACKGROUND OF ARTERIAL HYPERTENSION IN COMBINATION WITH NONCARDIAC DISEASES

, 2019
Л. Д. Хидирова, D. A. Yakhontov, В. Н. Максимов, Department of Pharmacology, Clinical Pharmacology and EvidenceBased Medicine, Novosibirsk State Medical University, Vladimir Nikolaevich Maksimov, Laboratory of Molecular Genetic Research of Therapeutic Diseases, Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences   +5 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Cost-effectiveness of population-based expanded reproductive carrier screening for genetic diseases in Australia: a microsimulation analysis. [PDF]

Eur J Hum Genet
Schofield D, Lee E, Parmar J, Castelo Taboada A, Hobbs M, Laing N, Shrestha R.   +6 more
europepmc   +1 more source

Additional file 2: of Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks

, 2018
Hyung Woo, Jaques Reifman
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50% [PDF]

Izaro Kortazar‐Zubizarreta, África Manero-Azua, Hasier Eraña, Urko Aguire, Joaquı́n Castilla, Guiomar Pérez de Nanclares   +5 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Clinical experience of the expanded carrier screening for recessive genetic diseases in a large cohort study in Southern central China. [PDF]

Sci Rep
Pan L, Luo H, Huang T, Yuan H, Zou Y, Lu Q, Zeng B, Ma P, Yang Y, Huang T, Liu D, Yang B, Liu Y, Zou J, Fu F.   +14 more
europepmc   +1 more source