Results 281 to 290 of about 13,340,828 (402)

Direct health-care costs for children diagnosed with genetic diseases are significantly higher than for children with other chronic diseases

Genetics in Medicine, 2018
D. Marshall, E. Benchimol, A. MacKenzie, D. Duque, K. MacDonald, T. Hartley, Heather E Howley, A. Hamilton, Meredith K. Gillespie, Faheem Malam, K. Boycott   +10 more
semanticscholar   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Clinical experience of the expanded carrier screening for recessive genetic diseases in a large cohort study in Southern central China. [PDF]

Sci Rep
Pan L, Luo H, Huang T, Yuan H, Zou Y, Lu Q, Zeng B, Ma P, Yang Y, Huang T, Liu D, Yang B, Liu Y, Zou J, Fu F.   +14 more
europepmc   +1 more source

Interactive influence of infectious disease and genetic diversity in natural populations

, 1988
Stephen J. O’Brien, James F. Evermann
openalex   +1 more source

URIDINE MONOPHOSPHATE KINASE (UMPK)-A NEW GENETIC MARKER FOR SUSCEPTIBILITY TO HAEMOPHILUS INFLUENZAE TYPE B (HIB) DISEASE [PDF]

, 1984
Gloria M. Petersen, Diana R. Silimperi, E.M. Scott, D L Hall, Jerome I. Rotter, Joel I. Ward   +5 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Editorial: The clinical utility of long read sequencing to improve diagnostic yield and uncover biological mechanisms in rare disease

Frontiers in Genetics
Lidia Larizza, Christopher M. Watson, Christopher M. Watson, Madelyn A. Gillentine, Palma Finelli, Palma Finelli   +5 more
doaj   +1 more source

Diagnostic Accuracy and Chromosomal Microarray and Karyotype Analysis with Different Clinical Biomarkers for Prenatal Diagnosis of Fetal Genetic Diseases. [PDF]

Iran J Public Health
Cai F, Shen R, Wang H, Zheng Y, Zhang W, Jin L.   +5 more
europepmc   +1 more source

Vaccines '88: New Chemicals and Genetic Approaches to Vaccination. Prevention of AIDS and other viral, bacterial and parasitic diseases. Edited by H. Ginsberg, F. Brown, R. A. Lerner and R. M. Channock. New York: Cold Spring Harbor Labortory. 1988. 396 pages. Paper $9500. ISBN 0 87969 210 X. [PDF]

, 1989
Robert G. Ridley
openalex   +1 more source

Post-mortem whole-exome analysis in a large sudden infant death syndrome cohort with a focus on cardiovascular and metabolic genetic diseases

European Journal of Human Genetics, 2017
Jacqueline Neubauer, M. Lecca, G. Russo, C. Bartsch, A. Medeiros-Domingo, W. Berger, C. Haas   +6 more
semanticscholar   +1 more source