Results 41 to 50 of about 2,355,082 (334)
FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases [PDF]
, 2009 Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease.
Heinrich, Joachim +3 more
core +1 more source
Genetics of Parkinson's disease
Dialogues in Clinical Neuroscience, 1998 A genetic contribution to the etiology of Parkinson's disease (PD) is now well established, based on the demonstration of a familial aggregation of the disease as demonstrated by several case–control and twin studies, and on the description of large multigenerational families, in whom PD is inherited in a Mendelian fashion.
openaire +11 more sources
The genetic basis of disease [PDF]
Essays in Biochemistry, 2018 Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal
Jackson, Maria +3 more
openaire +3 more sources
A dynamic network approach for the study of human phenotypes [PDF]
, 2009 The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases.
A Barrat +35 more
core +5 more sources
Association of ABCC8 and KCNJ11 gene variants with type 1 diabetes in south Indians
Egyptian Journal of Medical Human Genetics, 2021 Background Type 1 diabetes mellitus (TIDM) is a polygenic disorder with the involvement of several genetic and environmental risk factors. Mutation in genes namely ABCC8 and KCNJ11 disrupt the potentiality of KATP channel and regulates the secretion of ...
Shilpa Reddy +7 more
doaj +1 more source
Кардиоваскулярная терапия и профилактика, 2022 The formation of biobanks in the structure of scientific and treatment and diagnostic institutions with prospects for interregional integration is a fundamental link in monitoring and predicting diseases of various origins, creating and testing highly ...
R. S. Kalinin +16 more
doaj +1 more source
Annual Review of Pathology: Mechanisms of Disease, 2021 Genetic diseases cause numerous complex and intractable pathologies. DNA sequences encoding each human's complexity and many disease risks are contained in the mitochondrial genome, nuclear genome, and microbial metagenome. Diagnosis of these diseases has unified around applications of next-generation DNA sequencing.
Roth, Theodore L, Marson, Alexander
openaire +5 more sources
Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders
Population Ecology, EarlyView.We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa +2 more
wiley +1 more source
, 2011 Full text freely available at http://www.sciencemag.org/content/331/6020/1026.3.full or http://www.sciencemag.org/content/331/6020/1026.3.full.pdfInternational audienceThe sequencing of the human genome has been a major scientific adventure of the late ...
Rabeharisoa, Vololona
core +3 more sources
Mapping the genetic architecture of gene expression in human liver [PDF]
, 2008 Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits.
Avila-Campillo, I +30 more
core +3 more sources