Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]
, 2017 This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
core +1 more source
CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency.
Blood, 2016 CTLA-4 is a critical inhibitory "checkpoint" molecule of immune activation. Several recent reports have described patients with immune dysregulation and lymphoproliferative disease resulting from 2 different genetic diseases that directly or indirectly ...
Bernice Lo +5 more
semanticscholar +1 more source
Patterns of spatial genetic structures in Aedes albopictus (Diptera: Culicidae) populations in China. [PDF]
, 2019 BACKGROUND:The Asian tiger mosquito, Aedes albopictus, is one of the 100 worst invasive species in the world and the vector for several arboviruses including dengue, Zika and chikungunya viruses.
Fan, Peiyang +9 more
core
Medical Genetic Counseling Of Women With Congenital Heart Diseases Of Fetus [PDF]
, 2019 Aim of the work. Determine the effectiveness of prenatal diagnosis of congenital heart defects in the fetus and the informativeness of different markers used in the medical-genetic counseling of pregnant women..Materials and methods.
Helner, N. (Nadiya) +3 more
core +3 more sources
Viruses, 2019 Chikungunya (CHIK) is a febrile arboviral illness caused by chikungunya virus (CHIKV) and has been identified in more than 60 countries across the globe.
Jaspreet Jain +6 more
doaj +1 more source
Increasing the Discovery Power and Confidence Levels of Disease Association Studies: A Survey [PDF]
arXiv, 2017 The majority of common diseases are influenced by multiple genetic and environmental factors such as Cancer. Even though uncovering the main causes of disease is deemed difficult due to the complexity of gene-gene and gene-environment interactions, major research efforts aim at identifying disease risk factors, especially genetic ones.
arxiv
Integrative genetic risk prediction using nonparametric empirical Bayes classification [PDF]
, 2016 Genetic risk prediction is an important component of individualized medicine, but prediction accuracies remain low for many complex diseases. A fundamental limitation is the sample sizes of the studies on which the prediction algorithms are trained.
arxiv +1 more source
Human hepatic organoids for the analysis of human genetic diseases.
JCI Insight, 2017 We developed an in vitro model system where induced pluripotent stem cells (iPSCs) differentiate into 3-dimensional human hepatic organoids (HOs) through stages that resemble human liver during its embryonic development.
Y. Guan +11 more
semanticscholar +1 more source
A Strategy analysis for genetic association studies with known inbreeding [PDF]
, 2011 Background: Association studies consist in identifying the genetic variants which are related to a specific disease through the use of statistical multiple hypothesis testing or segregation analysis in pedigrees.
Bertolino, Francesco +9 more
core +2 more sources
Exploring the genetic patterns of complex diseases via the integrative genome-wide approach [PDF]
arXiv, 2015 Motivation: Genome-wide association studies (GWASs), which assay more than a million single nucleotide polymorphisms (SNPs) in thousands of individuals, have been widely used to identify genetic risk variants for complex diseases. However, most of the variants that have been identified contribute relatively small increments of risk and only explain a ...
arxiv