Results 261 to 270 of about 3,343,818 (361)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genetic Divergence Analysis in Pumpkin

Biological Sciences - PJSIR, 2013
Mohammad Amir Hossain Mollah, Mohammad Khalid Jamil, Mohammad Moniruzzaman, Shahabuddin Ahmad, Abul Khair Muhammad Quamruzzaman   +4 more
openaire   +2 more sources

Cytochrome b gene based phylogeny and genetic divergence of Tetraophasis of China

, 2010
Longying Wen, Naifa Liu
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Genetic divergence in population mean fitness is weakly associated with environmental and geographic distance in four prairie perennial forbs. [PDF]

Evol Lett
Peschel AR, Flint SA, May G, Shaw RG.
europepmc   +1 more source

Correction: Corrigendum: What drives phenotypic divergence in Leymus chinensis (Poaceae) on large-scale gradient, climate or genetic differentiation? [PDF]

, 2017
Shan Yuan, Linna Ma, Chengyuan Guo, Renzhong Wang   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Correction: Genetic divergence for adaptability and stability in sugarcane: Proposal for a more accurate evaluation. [PDF]

PLoS One
PLOS ONE Staff.
europepmc   +1 more source

INDEPENDENT AXES OF GENETIC VARIATION AND PARALLEL EVOLUTIONARY DIVERGENCE OF OPERCLE BONE SHAPE IN THREESPINE STICKLEBACK

, 2011
Charles B. Kimmel, William A. Cresko, Patrick C. Phillips, Bonnie Ullmann, Mark Currey, William von Hippel, Bjarni K. Kristjánsson, Ofer Gelmond, Katrina McGuigan   +8 more
openalex   +1 more source

MORPHOLOGICAL CHARACTERIZATION AND GENETIC DIVERGENCE IN MYANMAR SESAME (Sesamum indicum L.) GERMPLASM. [PDF]

, 2018
Myint Myint Aye, TinTin Khaing, NangHseng Hom   +2 more
openalex   +1 more source