Results 151 to 160 of about 92,865 (288)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Investigating the relative influence of genetic drift and natural selection in shaping patterns of population structure in Delphinids (Delphinus delphis; Tursiops spp.) [PDF]
, 2010 Speciation models relying on geographic barriers to limit gene flow gather widespread consensus, but are insufficient to explain diversification in highly mobile marine organisms.
MOURA, ANDRE,EURICO,VIOLA
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Ne/N ratio in applied conservation
Evolutionary ApplicationsRecent developments within the IUCN and the Convention on Biological Diversity have affirmed the increasingly key role that effective population size (Ne) and the effective size: census size ratio (Ne/N) play in applied conservation and management of ...
Robin S. Waples
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Faster Optimization Through Genetic Drift [PDF]
The compact Genetic Algorithm (cGA), parameterized by its hypothetical population size $K$, offers a low-memory alternative to evolving a large offspring population of solutions. It evolves a probability distribution, biasing it towards promising samples.
Florescu, Cella +3 more
core +1 more source
Minig rules of concept drift using genetic algorithm [PDF]
, 2011 In a database the data concepts changes over time and this phenomenon is called as concept drift. Rules of concept drift describe how the concept changes and sometimes they are interesting and mining those rules becomes more important.
Vivekanandan, P., Nedunchezhian, R.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source