Results 271 to 280 of about 3,031,778 (313)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Genetic drift versus regional spreading dynamics of COVID-19

, 2020
Pietro RD, Basile M, Antolini L, Alberti S.   +3 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Gene flow and genetic drift in urban environments

Molecular Ecology, 2019
Evidence is growing that human modification of landscapes has dramatically altered evolutionary processes. In urban population genetic studies, urbanization is typically predicted to act as a barrier that isolates populations of species, leading to ...
Lindsay S. Miles, L. Rivkin, Marc T. J. Johnson, J. Munshi-South, B. Verrelli   +4 more
semanticscholar   +1 more source

Update Strength in EDAs and ACO: How to Avoid Genetic Drift

Annual Conference on Genetic and Evolutionary Computation, 2016
We provide a rigorous runtime analysis concerning the update strength, a vital parameter in probabilistic model-building GAs such as the step size 1/K in the compact Genetic Algorithm (cGA) and the evaporation factor ρ in ACO.
Dirk Sudholt, C. Witt
semanticscholar   +1 more source

Drift happens: Molecular genetic diversity and differentiation among populations of jewelweed (Impatiens capensis Meerb.) reflect fragmentation of floodplain forests

Molecular Ecology, 2019
Landscape features often shape patterns of gene flow and genetic differentiation in plant species. Populations that are small and isolated enough also become subject to genetic drift.
Rachel H. Toczydlowski, D. Waller
semanticscholar   +1 more source

Rett syndrome and genetic drift

Brain and Development, 1999
An X chromosome gene is assumed to be responsible for the cause of Rett syndrome (RS). However, new genealogical observations suggest involvement of autosomal recessive gene(s) as well, at least in familial cases. To account for these and other recent observations, the theoretical model presented in 1990 by the authors of this paper is applied to the ...
E M, Bühler, N J, Malik, M, Alkan
openaire   +2 more sources

Population Genetics: Consanguinity, Genetic Drift

1997
Considerations in the preceding chapters presume random mating, and Hardy-Weinberg proportions are assumed to hold true. However, such assumptions are an abstraction. In modern outbreeding populations mating may approximate randomness for some genetic traits, such as blood groups and enzyme types, but is certainly nonrandom for some traits and some ...
Friedrich Vogel, Arno G. Motulsky
openaire   +1 more source

Dominance and Genetic Drift

Crop Science, 2003
Many public sector maize recurrent selection programs have been designed based on additive genetic expectations. Populations have been managed as large metapopulations with the assumption that population size must be very large because inbreeding due to finite size causes a linear reduction in genetic variance; we show that in BS13(S)C0 such ...
Jode W. Edwards, Kendall R. Lamkey
openaire   +1 more source