Results 111 to 120 of about 575,727 (342)
Expert consensus on BRCA1/2 gene testing and clinical application in Chinese breast cancer patients (2025 edition) [PDF]
Zhongguo aizheng zazhiBreast cancer remains one of the frequently diagnosed malignant tumors among Chinese women, with hereditary cases accounting for 5%-10% of all diagnoses, where BRCA1/2 gene mutations serve as the primary genetic predisposition factors.
WANG Hongxia, YIN Yongmei, HU Xichun
doaj +1 more source
Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation [PDF]
, 2023 Amit Agarwal +8 more
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Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source
From Entity Description to Semantic Analysis: The Case of Theodor Fontane’s Notebooks
Journal of the Text Encoding Initiative, 2015 Within the last few decades, TEI has become a major instrument for philologists in the digital age, particularly since a set of mechanisms has recently been incorporated which facilitates the encoding of genetic editions. Editors use the XML syntax while
Martin de la Iglesia, Mathias Göbel
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2010 Bright Ideas Conference Program [PDF]
, 2010 Event program for the 2010 Bright Ideas Conference at ...
Office of Research and Sponsored Programs
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Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Разработка и регистрация лекарственных средствIntroduction. The State Pharmacopoeia of the Russian Federation, XIV-th edition (SP XIV), includes 107 monographs devoted to medicinal plant materials. The purpose of the study was to identify incorrect Latin names of medicinal plants in the monographs ...
M. N. Povydysh, M. Yu. Goncharov
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ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source