Results 291 to 300 of about 575,727 (342)
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Genetic editing of dysfunctional myocardium
Medical Clinics of North America, 2003Ongoing advances in vector technology, cardiac gene delivery, and, most importantly, our understanding of HF pathogenesis, encourage consideration of gene therapy for HF at this time. At the present time, strategies that enhance sarcoplasmic calcium transport are supported by substantial evidence in both cardiomyocytes derived from patients with HF and
Roger J, Hajjar +3 more
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Non-GMO genetically edited crop plants
Trends in Biotechnology, 2015Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome editing complex is degraded in the ...
Nagamangala Kanchiswamy, Chidananda +4 more
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Genetic editing of wood for sustainability
Science, 2023Trees engineered to have less lignin could make paper production less ...
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Changing genetic information through RNA editing
BioEssays, 2000RNA editing, the post-transcriptional alteration of a gene-encoded sequence, is a widespread phenomenon in eukaryotes. As a consequence of RNA editing, functionally distinct proteins can be produced from a single gene. The molecular mechanisms involved include single or multiple base insertions or deletions as well as base substitutions.
S, Maas, A, Rich
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Digital Genetic Editing and Computer-Assisted Genetic Criticism
2022Abstract Instead of focusing on a single ‘work in progress’, this chapter discusses the need for genetic criticism on the level of the author’s complete works, the ‘oeuvre in motion’. It suggests ways of modelling genetic Complete Works editions, especially in a digital paradigm, and it discusses forms of close and distant reading of ...
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Insect Molecular Genetics (2nd Edition)
Annals of the Entomological Society of America, 2003AN APPRECIATION OF WHATmolecular biology can do for studies of insects has been slow in coming to many parts of the entomological community. I vividly recall the day a few years ago when an entomologist friend said tome: “You know,Dave, I Þnally understand how molecular biology can help us to answer some questions that we just couldnOt answer before ...
David Haymer, Hoy Marjorie
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Receptor editing: Genetic reprogramming of autoreactive lymphocytes
Cell Biochemistry and Biophysics, 1999The clonal selection theory postulates that immune tolerance mediated selection occurs at the level of the cell. The receptor editing model, instead, suggests that selection occurs at the level of the B-cell receptor, so that self-reactive receptors that encounter autoantigen in the bone marrow are altered through secondary rearrangement.
M W, Retter, D, Nemazee
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New clinical genetics—2nd edition
Journal of Medical Genetics, 2011Authored by Andrew Read, Dian Donnai. Published by Scion Publishing Ltd, Banbury, UK, 2011, pp 442, $65.00, ISBN: 978 1 904842 80 4 www.scionpublishing.com This is the second edition of this book, published first in 2007. It is the product of the joint efforts of a molecular geneticist, Professor Andrew Read, and a clinical geneticist, Professor Dian ...
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Genetically Edited Cascade Nanozymes for Cancer Immunotherapy
ACS NanoImmune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and insufficient infiltration of cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy to promote DC maturation and elicit T-cell immunity,
Jing Zhang +6 more
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