Results 61 to 70 of about 575,727 (342)

W rytmie kół: Zapiski Heleny Modrzejewskiej z amerykańskiego tournée w 1893 roku

Pamiętnik Teatralny, 2019
The paper analyses the current edition of Helena Modrzejewska's diary which is annotated with regard to its content: the events of the first six weeks of 1893, people described by Modrzejewska and their relationship with the actress, performances and ...
Dorota Jarząbek-Wasyl
doaj   +1 more source

Drift and evolutionary forces: scrutinizing the Newtonian analogy [PDF]

, 2016
This article analyzes the view of evolutionary theory as a theory of forces. The analogy with Newtonian mechanics has been challenged due to the alleged mismatch between drift and the other evolutionary forces. Since genetic drift has
Luque, Víctor J.
core  

Reasons and Reproduction: Gene Editing and Genetic Selection

The American Journal of Bioethics, 2023
Many writers in bioethics, science, and medicine contend that embryo selection is a morally better way of avoiding genetic disorders then gene editing, as the latter has risks that the former does not. We argue that one reason to use gene editing is that in many cases it would be better for the person who would develop from the edited embryo, so that ...
Jeff McMahan, Julian Savulescu
openaire   +3 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

'Nenhum Problema Tem Solução': Um Arquivo Digital do Livro do Desassossego

MatLit, 2013
The research project 'No Problem Has Solution: A Digital Archive of the Book of Disquiet' aims to produce a digital hypermedia archive of the Book of Disquiet [LdoD], by Bernardo Soares/Fernando Pessoa.
Manuel Portela
doaj   +1 more source

Automation on the generation of genome scale metabolic models [PDF]

, 2012
Background: Nowadays, the reconstruction of genome scale metabolic models is a non-automatized and interactive process based on decision taking. This lengthy process usually requires a full year of one person's work in order to satisfactory collect ...
de Córdoba, P. Fernández, Fuente, D., Gamermann, D., Montagud, A., Reyes, R., Triana, J., Urchuegía, J. F.   +6 more
core   +1 more source

Looking forward to genetically edited fruit crops [PDF]

Trends in Biotechnology, 2015
The availability of genome sequences for many fruit crops has redefined the boundaries of genetic engineering and genetically modified (GM) crop plants. However commercialization of GM crops is hindered by numerous regulatory and social hurdles. Here, we focus on recently developed genome-editing tools for fruit crop improvement and their importance ...
Nagamangala Kanchiswamy, Chidananda, Sargent, Daniel James, Velasco, Riccardo, Maffei, M. E., Malnoy, Mickael Arnaud   +4 more
openaire   +3 more sources

Genetic control of RNA editing in neurodegenerative disease

Briefings in Bioinformatics, 2022
Abstract A-to-I RNA editing diversifies human transcriptome to confer its functional effects on the downstream genes or regulations, potentially involving in neurodegenerative pathogenesis. Its variabilities are attributed to multiple regulators, including the key factor of genetic variants.
Sijia Wu, Qiuping Xue, Mengyuan Yang, Yanfei Wang, Pora Kim, Xiaobo Zhou, Liyu Huang   +6 more
openaire   +2 more sources

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source