Results 231 to 240 of about 1,062,704 (335)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Establishment of an Agrobacterium-mediated transformation system for the genetic engineering of Linum grandiflorum Desf. [PDF]

Physiol Plant
Gad K, Levchuk H, Kappel C, Lenhard M.
europepmc   +1 more source

Ethylene receptors and genetic engineering of ethylene sensitivity in plants.

, 1999
Kumi Sato‐Nara, Ken‐Ichi Yuhashi, Hiroshi Ezura   +2 more
openalex   +2 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Microalgae for bioremediation: advances, challenges, and public perception on genetic engineering. [PDF]

BMC Plant Biol
Calatrava V, Gonzalez-Ballester D, Dubini A.   +2 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Correction: A novel SfaNI-like restriction-modification system in Caldicellulosiruptor extents the genetic engineering toolbox for this genus. [PDF]

PLoS One
Swinnen S, Zurek C, Krämer M, Heger RM, Domeyer JE, Ziegler J, Svetlitchnyi VA, Läufer A.   +7 more
europepmc   +1 more source

Genetic engineering of a radiation-resistant bacterium for biodegradation of ixed wastes. 1998 annual progress report

, 1998
Mary E. Lidstrom
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Recent Advances in Genetic Engineering Strategies of <i>Sinorhizobium meliloti</i>. [PDF]

ACS Synth Biol
Liu X, Dong H, Wang H, Ren X, Yang X, Li T, Fu G, Xia M, Fang H, Du G, Jin Z, Zhang D.   +11 more
europepmc   +1 more source