Should Parents Design Their Children’s Genome: Some General Arguments and a Confucian Solution
Philosophies, 2019 With the emergence of clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) as one of the most promising new gene-editing techniques, scientists are now endeavoring to apply it to various domains.
Jianhui Li, Xin Zhang
doaj +1 more source
Mechanism of the enhanced epidermal growth factor-induced growth response of genetically hypertensive vascular myocytes. [PDF]
, 1991 R. D. Bukoski, Peggy DeWan, Jian-ping Bo
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Markovian Characterisation of H.264/SVC scalable video [PDF]
, 2008 In this paper, a multivariate Markovian traffic: model is proposed to characterise H.264/SVC scalable video traces. Parametrisation by a genetic algorithm results in models with a limited state space which accurately capture.
Bruneel, Herwig +3 more
core
ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function
FEBS Letters, EarlyView.The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran +6 more
wiley +1 more source
Editorial: Trait mining and genetic enhancement of millets and potential crops: modern prospects for ancient grains. [PDF]
Front Plant Sci, 2023 Joshi DC +4 more
europepmc +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
Genetic enhancement: an avenue to combat aging-related diseases. [PDF]
Life Med, 2022 Cai Y +6 more
europepmc +1 more source
Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes [PDF]
, 1998 Anja Krause +5 more
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A Bayesian method for identification of stock mixtures from molecular marker data [PDF]
, 2006 Molecular markers have been demonstrated to be useful for the estimation of stock mixture proportions where the origin of individuals is determined from baseline samples.
Corrander, Jukka +2 more
core
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source