Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Crossbreeding East African Highland Bananas: Lessons Learnt Relevant to the Botany of the Crop After 21 Years of Genetic Enhancement. [PDF]
Batte M +8 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Genetic enhancement of lodging resistance in rice due to the key cell wall polymer lignin, which affects stem characteristics. [PDF]
Liu S +5 more
europepmc +1 more source
ENHANCING DEEP LEARNING PERFORMANCE THROUGH A GENETIC ALGORITHM-ENHANCED APPROACH: FOCUSING ON LSTM
Tarık Üveys Şen, Gokhan Bakal
openalex +2 more sources
Encapsulation-enhanced genetic switches in lactobacilli [PDF]
Marc Blanch‐Asensio +6 more
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. [PDF]
Yang J +12 more
europepmc +1 more source
Advancing Embryonic Growth through Genetic Stimulation to Enhance Development in Chicken Embryos [PDF]
Oady Lafthali, S. M. Abdulateef
openalex +1 more source

