Results 191 to 200 of about 259,867 (296)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin. [PDF]

Sci Rep, 2018
Ruiz-DeDiego I, Fasano S, Solís O, Garcia-Montes JR, Brea J, Loza MI, Brambilla R, Moratalla R.   +7 more
europepmc   +1 more source

Mechanisms of enhancing genetic fitness in Non-Kinship-Based Groups: Insights from Black-necked Cranes

Yuhang Li, Yuyi Jin, Xingcheng He, Liang Dou, Penghui He, Yichuan Zhang, Zhongqiu Li, Jianghong Ran   +7 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome. [PDF]

Am J Med Genet C Semin Med Genet, 2016
Lopez-Burks ME, Santos R, Kawauchi S, Calof AL, Lander AD.   +4 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Genetic enhancement of phosphorus starvation tolerance through marker assisted introgression of OsPSTOL1 gene in rice genotypes harbouring bacterial blight and blast resistance. [PDF]

PLoS One, 2018
Chithrameenal K, Alagarasan G, Raveendran M, Robin S, Meena S, Ramanathan A, Ramalingam J.   +6 more
europepmc   +1 more source

Development of a Chemical Genetic Screen to Identify Compounds that Enhance Laromustine Cytotoxicity

, 2019
Xiaoou Wang
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Phenotypic and Marker-Assisted Genetic Enhancement of Parental Lines of Rajalaxmi, an Elite Rice Hybrid. [PDF]

Front Plant Sci, 2016
Dash AK, Rao RN, Rao GJ, Verma RL, Katara JL, Mukherjee AK, Singh ON, Bagchi TB.   +7 more
europepmc   +1 more source