Results 241 to 250 of about 259,867 (296)

eVGeMdb: a manually curated database for experimentally validated genetic modifiers of neurodegenerative disorders. [PDF]

NAR Mol Med
Singh S, Singh P, Varada MP, Vijaivasudev MJ, Kumar R, Malik I.   +5 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Retraction Note: Enhancement of novel Endo-polygalacturonase expression in Rhodotorula mucilaginosa PY18 : insights from mutagenesis and molecular docking. [PDF]

Microb Cell Fact
El-Aziz NMA, Moharam ME, El-Gamal NN, Khalil BE.   +3 more
europepmc   +1 more source

An intronic genetic variation of MGMT affects enhancer activity and is associated with glioma susceptibility

, 2018
L Huang, Xu W, Dai Liu, Da Yan, Shu-Yi ZHANG, Xun Shi   +5 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A case report in hypertrophic cardiomyopathy in a recreational athlete: multimodality risk assessment, genetic insights, and shared decision-making. [PDF]

Eur Heart J Case Rep
Gomez LE, Aversa E, Saenz Tejeira MM, Buonfiglio P, Atamañuk N.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multifocal anaplastic astrocytoma mimicking primary central nervous system lymphoma: A case report. [PDF]

Medicine (Baltimore)
Yang B, Liu H, You G, Wen S, Tang Y.
europepmc   +1 more source

Hybrid genetic algorithm with interpretable surrogate modeling for enhanced optimization of short-fiber reinforced polymer composites

Yiqun Dong, Zhenyue Chen, Yunmei Zhao
openalex   +1 more source

Genetic Enhancement

, 2016
openaire   +1 more source