Results 121 to 130 of about 8,430,932 (306)

UHPLC-MS/MS-Based Metabolomics Identifies Freshness Biomarkers and Temporal Spoilage Threshold in Refrigerated Goose Meat

Foods
The dynamic metabolic landscape underlying goose meat quality deterioration during refrigerated storage remains incompletely elucidated. Here, ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)-based widely targeted ...
Wen Gao, Zhengfeng Cao, Qiang Bao, Qingping Tang, Zhu Bu, Guohong Chen, Bichun Li, Qi Xu   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Integration ATAC‐Seq and RNA‐Seq Analysis of Mammary Placodes in Erhualian and Bamaxiang Pigs Identified Candidate Genes Influencing Pig Teat Number Variation

Evolutionary Applications
Teat number is an important economic trait in pigs, affecting piglet health and survival. While numerous GWAS have identified candidate genes for teat number in Duroc, Landrace, and Large White pigs, the causal genes remain unclear, largely due to a lack
Chenxi Liu, Ruihua Huang, Nengjing Jiang, Wuduo Zhou, Qian Liu, Taoran Du, Qian Zhang, Jinfeng Ma, Qingbo Zhao, Pinghua Li   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Multi-omics analysis identifies key genes and functional loci affecting teat number in American Large White and Landrace pigs and their application in optimizing genomic selection models

BMC Genomics
Background Teat number is a crucial economic trait in pigs. It directly affects the ability of sows to lactate, which in turn influences the survival and health of piglets.
Jinfeng Ma, Xinjie Ai, Yun Hao, Yanzhen Yin, Qian Liu, Jianghui Yu, Jin Zhou, Fusheng Wang, Liang Shuai, Yikun Jin, Ruihua Huang, Qingbo Zhao, Pinghua Li   +12 more
doaj   +1 more source

Root system architecture and drought adaptation: emerging tools and genetic insights

Frontiers in Plant Science
Strategic optimisation of Root System Architecture (RSA) represents a critical frontier for stabilising crop productivity amid increasingly unpredictable moisture-deficit regimes.
Vikender Kaur, Shashank Kumar Yadav, Bindu Yadav, Sukham Madaan, Munisha Kheralia, Viswanathan Chinnusamy   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Identification of a locus on Agropyron cristatum chromosome 6P that interacts with wheat genes to produce yellow–green leaves

BMC Plant Biology
Background Wide hybridization is crucial for broadening the genetic basis of common wheat. Agropyron cristatum (2n = 4x = 28, PPPP), a wild relative of wheat, harbors numerous favorable genes for genetic improvement.
Kai Qi, Haiming Han, Yuqing Lu, Jinpeng Zhang, Shenghui Zhou, Baojin Guo, Weihua Liu, Xiuquan Li, Xinming Yang, Xu Liu, Lihui Li   +10 more
doaj   +1 more source

Design and analysis of evaluation trials of genetic resources collections: A guide for genebank managers

, 2019
This guide is for genebank managers who are considering undertaking evaluation trials on the genetic material in their care. It covers the stages involved in an experimental programme, from the determination of the objectives of each trial to the methods
International Plant Genetic Resources Institute
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source