Results 201 to 210 of about 2,075,021 (307)

Comprehensive farm-level analysis of environmental and management descriptors for developing an efficient genetic evaluation of pasture-raised beef cattle. [PDF]

Transl Anim Sci
Santana TEZ, Veroneze R, Menezes GRO, Rosa GJM.   +3 more
europepmc   +1 more source

Multi-breed genetic evaluation for docility in Irisch Suckler Beef Cattle [PDF]

, 2009
Evans, R.D., Kearney, F., Mulder, H.A., Pabiou, T.   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Genetic Evaluation of Barrel Racing Performance in Quarter Horses. [PDF]

J Anim Breed Genet
Santana ML, Franco TGB, Bignardi AB.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Genetic Evaluation of Early Growth Traits in Yunnan Semi-Fine Wool Sheep. [PDF]

Animals (Basel)
Wang Y, Yang H, Zhao X, Ni X, Zhao Y, You Z, Lu Q, Tang S, Quan G, Fu X.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Conservation genetic evaluation of Juniperus communis sensu lato in Slovakia. [PDF]

Sci Rep
Klobučník M, Kormuťák A, Jurčík J, Galgóci M.   +3 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Incomplete Family History and Meeting Algorithmic Criteria for Genetic Evaluation of Hereditary Cancer.

JAMA Netw Open
Harris A, Bather JR, Bradshaw RL, Kawamoto K, Del Fiol G, Kohlmann WK, Chavez-Yenter D, Monahan R, Chambers RL, Sigireddi M, Goodman MS, Kaphingst KA.   +11 more
europepmc   +1 more source