Results 291 to 300 of about 2,077,052 (339)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Phylogenetic analysis and genetic evaluation of the Echinococcus granulosus antigen B subunit 2 gene isolated from sheep in Al-Diwaniyah, Iraq. [PDF]

Open Vet J
Hamad WA, Jawad TI, Atiya WH.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

First genetic evaluation of a wild population of Crocodylus intermedius: New insights for the recovery of a Critically Endangered species. [PDF]

PLoS One
Castillo-Rodríguez N, Saldarriaga-Gómez AM, Antelo R, Vargas-Ramírez M.   +3 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Evolving Role of Genetic Evaluation in the Prenatal Diagnosis and Management of Congenital Heart Disease. [PDF]

J Cardiovasc Dev Dis
Bucholz EM, Morton SU, Madriago E, Roberts AE, Ronai C.   +4 more
europepmc   +1 more source

S1 Table - Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines

Spencer C. Wei (20775665), Aaron J. Cantor (20775662), Jack Walleshauser (21594505), Rina Mepani (21594508), Kory Melton (20775647), Ashil Bans (21594511), Prachi Khekare (20775653), Suhani Gupta (20381642), Jonathan Wang (2652541), Craig Soares (21594514), Radwan Kiwan (21594517), Jieun Lee (483089), Shannon McCawley (20775656), Vihasi Jani (12369128), Weng In Leong (20775650), Pawan K. Shahi (11936549), Jean Chan (20775659), Pierre Boivin (9676739), Peter Otoupal (9637488), Bikash R. Pattnaik (11936555), David M. Gamm (11710727), Krishanu Saha (2442976), Benjamin G. Gowen (20775644), Mary Haak-Frendscho (14999742), Mary J. Janatpour (15033524), Adam P. Silverman (260053)   +25 more
openalex   +1 more source

Genetic Parameters for Limousine Interbeef Genetic Evaluation of Calving Traits. [PDF]

Genes (Basel)
Veselá Z, Brzáková M, Novotná A, Vostrý L.   +3 more
europepmc   +1 more source

Statistical approaches to genetic evaluation for threshold binary traits

, 1991
Jean Louis J. L. Foulley, Eduardo Manfredi   +1 more
openalex   +1 more source

Technical Considerations for Blood RNA Sequencing in Genetic Testing: Evaluation of Globin Depletion Methods, Batch Effects, and Sample Types

Xinyi Lu, Yumeng Ma, Xiaomei Luo, Xiaoyan Huo, Jie Wang, Yi Liu, Huili Liu, Ting Xu, Qianfeng Zhao, Yongguo Yu, Yanjie Fan   +10 more
openalex   +1 more source