Results 201 to 210 of about 56,963 (262)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The Genetics of Atrial Fibrillation: From Molecular Mechanisms to Precision Medicine. [PDF]

Cureus
Hinge DD, Shelke A, Kawade R, Patil S.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Obesity and Its Role in Fetal Programming-A Narrative Review. [PDF]

Nutrients
Mierzyński R, Poniedziałek-Czajkowska E, Świda K, Mierzyńska K.   +3 more
europepmc   +1 more source

Cross-Generational Integration of Exercise and Nutritional Encoding in Offspring Adipose Genomics. [PDF]

Int J Mol Sci
Chae SA, Yoo C, Son JS.
europepmc   +1 more source

Early postnatal antibiotic-associated gut microbiota alterations might promote long-term lipid metabolism via brown adipose tissue metabolic programming. [PDF]

Gut Microbes
Liang H, Jiang F, Ren L, Li X, Wu S, Li J, Li L, Ze X, Shen X, He F.   +9 more
europepmc   +1 more source

IGM: Integrated Gene-expression Modeling for multi-condition flux-preserving genome-scale metabolic models. [PDF]

PLoS One
Paklao T, Suratanee A, Plaimas K.
europepmc   +1 more source

Nutritional Regulation of Reproductive Physiology in Ruminants: A Mechanistic Review. [PDF]

Life (Basel)
Kang TC, Fan GJ, Lin HH, Tseng KF, Liu YC, Wu HH.   +5 more
europepmc   +1 more source

Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk. [PDF]

Int J Mol Sci
Hsu CN, Tain YL.
europepmc   +1 more source