Results 221 to 230 of about 7,966,330 (339)

Large language model based mutations in genetic improvement. [PDF]

Autom Softw Eng
Brownlee AEI, Callan J, Even-Mendoza K, Geiger A, Hanna C, Petke J, Sarro F, Sobania D.   +7 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A review of sustainable cattle genetic improvement in the Peruvian Highlands. [PDF]

Vet Anim Sci
Alvarez-García W, Muñoz-Vílchez Y, Figueroa D, Estrada R, Quilcate C.   +4 more
europepmc   +1 more source

Genetic Counselor Integration Improves Genetic Eye Disease Diagnostics

Ophthalmology Retina
Mark Lindquist, Jennifer Cech, Amanda Peterson, Jennifer Huey, Debarshi Mustafi   +4 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Telomere-to-telomere genome assembly of linseed (Linum usitatissimum L.) for functional genomics and accelerated genetic improvement. [PDF]

Plant Biotechnol J
Yadav HK, Singh N, Singh B, Kaur V, Sawant SV.   +4 more
europepmc   +1 more source

Cassava genetic improvement [PDF]

, 2017
Calle, Fernando, Ceballos, H., Jaramillo, Gustavo, Lenis, Jorge I., Morante, Nelson, Pérez, Juan Carlos   +5 more
core  

Genetic improvement in Pleurotus (oyster mushroom): a review

3 Biotech, 2019
Anupam Barh, V. Sharma, S. Annepu, Shwet Kamal, Shweta Sharma, P. Bhatt   +5 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Utilization of the <i>Dasypyrum</i> genus for genetic improvement of wheat. [PDF]

Mol Breed
Zhang J, Chen Q, Yang F, Wang Y, Xiao J, Ding H, Ma Q, Deng Q, Jiang Y.   +8 more
europepmc   +1 more source