Results 121 to 130 of about 342,848 (311)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

A major genetic locus in Trypanosoma brucei is a determinant of host pathology [PDF]

, 2009
The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has ...
C. Michael R. Turner, Andy Tait, Tait Andy, Liam J Morrison, McLellan Sarah, C Michael R Turner, Annette MacLeod, Liam J. Morrison, Turner, C.M.R., Sweeney Lindsay, MacLeod Annette, Lindsay Sweeney, MacLeod, A., McLellan, S., MacLeod, Annette, Tait, Andy, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Morrison Liam J., Sweeney, L., Turner C. Michael R., Morrison, Liam J; id_orcid, Tait, A., Sarah McLellan   +25 more
core   +1 more source

Linkage disequilibrium and genetic variability

Genetical Research, 1974
SUMMARYIt has been shown previously that, even in the absence of linkage, selection can cause an appreciable change in the genetic variance of a metric character due to disequilibrium; this change is temporary and is rapidly reversed when selection ceases.
openaire   +2 more sources

The use of different clustering methods in the evaluation of genetic diversity in upland cotton

Revista Ciência Agronômica, 2014
The continuous development and evaluation of new genotypes through crop breeding is essential in order to obtain new cultivars. The objective of this work was to evaluate the genetic divergences between cultivars of upland cotton (Gossypium hirsutum L ...
Laíse Ferreira de Araújo, Wener Santos de Almeida, Cândida Hermínia Campos de Magalhães Bertini, Francisco das Chagas Vidal Neto, Ervino Bleicher   +4 more
doaj  

Genome survey and high-resolution backcross genetic linkage map construction of the ridgetail white prawn Exopalaemon carinicauda applications to QTL mapping of growth traits

BMC Genomics, 2019
Background High-resolution genetic linkage map is critical for QTL mapping, genome sequence assembly and marker-assisted selection in aquaculture species.
Jitao Li, Jianjian Lv, Ping Liu, Ping Chen, Jiajia Wang, Jian Li   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mapping and Validation of the Major Sex-Determining Region in Nile Tilapia (Oreochromis niloticus L.) Using RAD Sequencing [PDF]

, 2013
Sex in Oreochromis niloticus (Nile tilapia) is principally determined by an XX/XY locus but other genetic and environmental factors also influence sex ratio.
McAndrew Brendan J., John B Taggart, David J Penman, Palaiokostas Christos, Mohd G Q Khan, Christos Palaiokostas (432876), Michaël Bekaert, Karim Gharbi (432878), Karim Gharbi, Bekaert, Michaël, Penman David J., John B. Taggart (208020), Christos Palaiokostas, Taggart, John, Mohd G. Q. Khan (432877), Penman, David J, Taggart John B., Khan, Mohd Golam Quader, Brendan J McAndrew, Michaël Bekaert (121005), Bekaert Michaël, Penman, David, Taggart, John B, Khan Mohd G. Q., McAndrew, Brendan J, Gharbi, Karim, Khan, Mohd G Q, David J. Penman (308424), Palaiokostas, Christos, McAndrew, Brendan, Brendan J. McAndrew (308428), Gharbi Karim   +31 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

THE GENETIC BASIS OF PRIMARY ADULT-ONSET DYSTONIA [PDF]

, 2011
Objectives. To identify novel genetic loci associated with primary adult-onset dystonia (AOD) and assess candidate genes from the literature. Secondary aimes.
Esposito, Marcello
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source