Results 191 to 200 of about 1,474,286 (302)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

HLA-DQB1*05:02: A Novel Genetic Marker for Susceptibility to Oral Cavity Squamous Cell Carcinoma. [PDF]

Cancer Med
Huang SF, Chien HT, Young CK, Lee YS, Liao CT, Cho KL, Chen CH, Chao A.   +7 more
europepmc   +1 more source

Genome-wide genetic marker analysis and genotyping of Escherichia fergusonii strain OTSVEF-60. [PDF]

Braz J Microbiol, 2021
Saha O, Rakhi NN, Hoque MN, Sultana M, Hossain MA.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Multiple Mutations-A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16-Positive Oropharyngeal Carcinoma. [PDF]

Laryngoscope Investig Otolaryngol
Graessle R, Piwonski I, Husemann C, Kleo K, Sabtan D, Franzen A, Olze H, Erben U, Hummel M, Coordes A.   +9 more
europepmc   +1 more source

APOE - a genetic marker of comorbidity in subjects with morbid obesity. [PDF]

BMC Med Genet, 2020
Farup PG, Rootwelt H, Hestad K.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Haemoglobin revisited: delineating population structure with the world's first molecular genetic marker used in fisheries research. [PDF]

R Soc Open Sci
Breistein B, Dahle G, Johansen T, Jorde PE, Glover KA.   +4 more
europepmc   +1 more source

Characterization of Met25 as a color associated genetic marker in Yarrowia lipolytica. [PDF]

Metab Eng Commun, 2020
Edwards H, Yang Z, Xu P.
europepmc   +1 more source

Estimation of Cry3Bb1 resistance allele frequency in field populations of western corn rootworm using a genetic marker. [PDF]

G3 (Bethesda), 2021
Willse A, Flagel L, Head G.
europepmc   +1 more source