Results 301 to 310 of about 1,500,690 (354)
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Current Opinion in Biotechnology, 1991
Advances in our understanding of polymorphisms found in eukaryotic genomes and improved methods for studying genetic markers should facilitate genetic linkage mapping and other applications. Progress within the past year includes characterization of the types, frequencies, and properties of tandemly repeated sequences, methods for obtaining the DNA ...
A, Edwards, C T, Caskey
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Advances in our understanding of polymorphisms found in eukaryotic genomes and improved methods for studying genetic markers should facilitate genetic linkage mapping and other applications. Progress within the past year includes characterization of the types, frequencies, and properties of tandemly repeated sequences, methods for obtaining the DNA ...
A, Edwards, C T, Caskey
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Beyond genetic markers: hypertension genes
Journal of Hypertension, 1994The dissection of the molecular genetics of hypertension is both a complex multidisciplinary challenge and a medical imperative. The Identification of hypertension genes will allow the dissection of etiologic mechanisms: the primary gene dysfunctions, gene interaction, and gene and environmental factor interaction, thus unravelling the heterogeneous ...
V L, Herrera, N, Ruiz-Opazo
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Journal of the American College of Surgeons, 2001
Sepsis is a systemic response to severe infection. Clinical sepsis is defined as an infection-induced syndrome including at least two of the features of systemic inflammatory response syndrome: fever or hypothermia (oral temperature .38°C or ,36°C); leukocytosis (.12,000 WBC/mm) or leukopenia (,4,000 WBC/ mm); tachycardia (heart rate .90 beats/minute);
A R, Tabrizi +3 more
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Sepsis is a systemic response to severe infection. Clinical sepsis is defined as an infection-induced syndrome including at least two of the features of systemic inflammatory response syndrome: fever or hypothermia (oral temperature .38°C or ,36°C); leukocytosis (.12,000 WBC/mm) or leukopenia (,4,000 WBC/ mm); tachycardia (heart rate .90 beats/minute);
A R, Tabrizi +3 more
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The Lancet, 1984
Narcolepsy has long been known to have a hereditary familial basis. All of 37 patients with narcolepsy expressed the major histocompatibility complex antigen HLA DR2 compared with 21.5% of 200 normal controls. This finding confirms the genetic basis for the disease, and furthermore links it with the short arm of chromosome 6.
N, Langdon +4 more
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Narcolepsy has long been known to have a hereditary familial basis. All of 37 patients with narcolepsy expressed the major histocompatibility complex antigen HLA DR2 compared with 21.5% of 200 normal controls. This finding confirms the genetic basis for the disease, and furthermore links it with the short arm of chromosome 6.
N, Langdon +4 more
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Russian Journal of Genetics, 2010
Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and morphological indices (Clark model). Alterations of genes in melanomas are discussed in detail.
V A, Tronov +2 more
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Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and morphological indices (Clark model). Alterations of genes in melanomas are discussed in detail.
V A, Tronov +2 more
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Genetic Markers in Schizophrenia
Human Heredity, 1986A genetic contribution to schizophrenia is the best established aetiological clue for this common and serious condition. Purely statistical attempts to establish the mode of inheritance have yielded inconclusive results although SML models where a major gene is the sole cause of concordance between relatives can be effectively excluded. The question of
P, McGuffin, E, Sturt
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1995
Abstract Linkage analysis can only be performed on loci that are polymorphic with two or more distinguishable alleles. Naturally occurring polymorphic loci with clear single-gene effects are rarely observed in wild animal populations.
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Abstract Linkage analysis can only be performed on loci that are polymorphic with two or more distinguishable alleles. Naturally occurring polymorphic loci with clear single-gene effects are rarely observed in wild animal populations.
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2019
Psychiatric disorders such as addiction (substance use and addictive disorders), depression, eating disorders, schizophrenia, and post-traumatic stress disorder (PTSD) are severe, complex, multifactorial mental disorders that carry a high social impact, enormous public health costs, and various comorbidities as well as premature morbidity.
Pivac, Nela +5 more
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Psychiatric disorders such as addiction (substance use and addictive disorders), depression, eating disorders, schizophrenia, and post-traumatic stress disorder (PTSD) are severe, complex, multifactorial mental disorders that carry a high social impact, enormous public health costs, and various comorbidities as well as premature morbidity.
Pivac, Nela +5 more
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GENETIC MARKERS IN THYROID NEOPLASIA
Endocrinology and Metabolism Clinics of North America, 2001Cancer is a disease of genes. Detection of genetic abnormalities associated with cancers of various cell types can now be used for genetic counseling, diagnosis or treatment selection. In the case of thyroid cancer, genetic testing for mutations of the RET oncogene has had a profound effect on the management of medullary thyroid carcinomas.
PUXEDDU, Efisio, Fagin J. A.
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JAMA: The Journal of the American Medical Association, 1973
To the Editor.— In the article by Gelpi and Perrine (224:605, 1973), part of the speculation on the origin of the sickle cell gene is based on an error in fact. The authors state "... it is clear that the R o (cDe) blood group gene complex, considered to be a reliable genetic marker for African Negro populations, occurs at high frequency among the ...
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To the Editor.— In the article by Gelpi and Perrine (224:605, 1973), part of the speculation on the origin of the sickle cell gene is based on an error in fact. The authors state "... it is clear that the R o (cDe) blood group gene complex, considered to be a reliable genetic marker for African Negro populations, occurs at high frequency among the ...
openaire +2 more sources