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Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto+5 more
wiley +1 more source
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi+5 more
wiley +1 more source
Description of genetic diversity within Brassica oleracea using isoenzymatic and molecular markers.
E. Margalé+3 more
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Genome-wide genetic marker discovery and genotyping using next-generation sequencing
Nature Reviews Genetics, 2011John W Davey+2 more
exaly +2 more sources
Genetic Markers in Sepsis [PDF]
Sepsis is a systemic response to severe infection. Clinical sepsis is defined as an infection-induced syndrome including at least two of the features of systemic inflammatory response syndrome: fever or hypothermia (oral temperature .38°C or ,36°C); leukocytosis (.12,000 WBC/mm) or leukopenia (,4,000 WBC/ mm); tachycardia (heart rate .90 beats/minute);
Barbara A. Zehnbauer+3 more
openaire +2 more sources
GENETIC MARKERS IN THYROID NEOPLASIA [PDF]
Cancer is a disease of genes. Detection of genetic abnormalities associated with cancers of various cell types can now be used for genetic counseling, diagnosis or treatment selection. In the case of thyroid cancer, genetic testing for mutations of the RET oncogene has had a profound effect on the management of medullary thyroid carcinomas.
PUXEDDU, Efisio, Fagin J. A.
openaire +3 more sources
Russian Journal of Genetics, 2010
Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and morphological indices (Clark model). Alterations of genes in melanomas are discussed in detail.
L. B. Gorbacheva+2 more
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Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and morphological indices (Clark model). Alterations of genes in melanomas are discussed in detail.
L. B. Gorbacheva+2 more
openaire +3 more sources
The Lancet, 1984
Narcolepsy has long been known to have a hereditary familial basis. All of 37 patients with narcolepsy expressed the major histocompatibility complex antigen HLA DR2 compared with 21.5% of 200 normal controls. This finding confirms the genetic basis for the disease, and furthermore links it with the short arm of chromosome 6.
David Parkes+9 more
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Narcolepsy has long been known to have a hereditary familial basis. All of 37 patients with narcolepsy expressed the major histocompatibility complex antigen HLA DR2 compared with 21.5% of 200 normal controls. This finding confirms the genetic basis for the disease, and furthermore links it with the short arm of chromosome 6.
David Parkes+9 more
openaire +3 more sources
Current Opinion in Biotechnology, 1991
Advances in our understanding of polymorphisms found in eukaryotic genomes and improved methods for studying genetic markers should facilitate genetic linkage mapping and other applications. Progress within the past year includes characterization of the types, frequencies, and properties of tandemly repeated sequences, methods for obtaining the DNA ...
Charles T. Caskey, Albert O. Edwards
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Advances in our understanding of polymorphisms found in eukaryotic genomes and improved methods for studying genetic markers should facilitate genetic linkage mapping and other applications. Progress within the past year includes characterization of the types, frequencies, and properties of tandemly repeated sequences, methods for obtaining the DNA ...
Charles T. Caskey, Albert O. Edwards
openaire +3 more sources
Genetic Markers in Schizophrenia
Human Heredity, 1986A genetic contribution to schizophrenia is the best established aetiological clue for this common and serious condition. Purely statistical attempts to establish the mode of inheritance have yielded inconclusive results although SML models where a major gene is the sole cause of concordance between relatives can be effectively excluded. The question of
Peter McGuffin, Elizabeth Sturt
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