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Genetic markers in methotrexate treatments
The Pharmacogenomics Journal, 2018Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of different cancers and autoimmune diseases. Despite the successful results observed, the main disadvantage lies in interpatient variability in the pharmacokinetic and pharmacodynamic parameters.
Andrea Giletti, Patricia Esperon
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Genetic Markers in Carcinoma of the Prostate
European Urology, 1984The distribution of phenotypes and gene frequencies of the third component of complement (C3), group-specific component (Gc), haptoglobin (Hp) and transferrin (Tf) were studied in 115 patients with carcinoma of the prostate. The statistical analysis of our findings in comparison to the frequency of these genes in a control group of 155 patients with ...
Germenis, A +5 more
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Genetic markers and cancer epidemiology
Cancer, 1977The study of potential associations between genetic markers and various cancers has a long history in cancer epidemiology. Such investigations are subject to serious problems of statistical significance and the choice of appropriate control populations.
Mary Claire King +2 more
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Prothrombotic genetic markers.
Italian heart journal : official journal of the Italian Federation of Cardiology, 2002The last decade has been characterized by an explosion of research studies on genetic epidemiology. In particular, as far as ischemic heart disease is concerned, a lot of research was focused on prothrombotic genetic risk factors. Unfortunately, the success of this approach in the field of venous thrombosis has not been replicated in the field of ...
Rossi M L, Merlini P A, Ardissino D
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JAMA: The Journal of the American Medical Association, 1973
To the Editor.— In the article by Gelpi and Perrine (224:605, 1973), part of the speculation on the origin of the sickle cell gene is based on an error in fact. The authors state "... it is clear that the R o (cDe) blood group gene complex, considered to be a reliable genetic marker for African Negro populations, occurs at high frequency among the ...
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To the Editor.— In the article by Gelpi and Perrine (224:605, 1973), part of the speculation on the origin of the sickle cell gene is based on an error in fact. The authors state "... it is clear that the R o (cDe) blood group gene complex, considered to be a reliable genetic marker for African Negro populations, occurs at high frequency among the ...
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PowerMarker: an integrated analysis environment for genetic marker analysis
Bioinform., 2005Kejun Liu, S. Muse
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Genetic Markers in Human Hypertension
American Journal of Hypertension, 1991A rapidly increasing abundance of genetic markers which can be characterized on a large scale makes an application of the genetic linkage strategy, so successful with Mendelian diseases, ever more attractive for genetic investigations of common diseases such as essential hypertension.
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Translocations as Genetic Markers
1994If two nonhomologous chromosomes interchange ends following chromosome breakage, the products of this event are termed a reciprocal interchange or reciprocal translocation. The two rearranged chromosomes that result are fully stable and, when transmitted together, contain all the chromosomal material that was present in the two normally arranged ...
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Linkage and Association to Genetic Markers
2015Genetic markers that are sufficiently polymorphic (as measured by their heterozygosities) can be used in linkage and association analyses to detect Mendelian segregation underlying disease phenotypes. Each type of analysis can either be based on a specific genetic model or not make any assumptions about the mode of inheritance of the disease ...
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