Results 71 to 80 of about 1,500,690 (354)

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. [PDF]

, 2013
BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in ...
Baldassarre, Damiano, Casas, Juan-Pablo, de Faire, Ulf, Deanfield, John, Drenos, Fotios, Gertow, Karl, Gigante, Bruna, Hamsten, Anders, Hingorani, Aroon D, Holmes, Michael V, Humphries, Steve E, Kivimaki, Mika, Kumari, Meena, Langenberg, Claudia, Sennblad, Bengt, Shah, Sonia, Strawbridge, Rona J, Swerdlow, Daniel I, Talmud, Philippa J, Tremoli, Elena, Veglia, Fabrizio, Wareham, Nick, Whittaker, John   +22 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Different processes shape the patterns of divergence in the nuclear and chloroplast genomes of a relict tree species in East Asia

Ecology and Evolution, 2020
Isolation by spatial distance (IBD), environment (IBE), and historical climatic instability (IBI) are three common processes assessed in phylogeographic and/or landscape genetic studies.
Xiang‐Yu Tian, Jun‐Wei Ye, Tian‐Ming Wang, Lei Bao, Hong‐Fang Wang   +4 more
doaj   +1 more source

Homozygosity and risk of childhood death due to invasive bacterial disease. [PDF]

, 2009
BACKGROUND: Genetic heterozygosity is increasingly being shown to be a key predictor of fitness in natural populations, both through inbreeding depression, inbred individuals having low heterozygosity, and also through chance linkage between a marker and

core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Random Forest as a tumour genetic marker extractor [PDF]

, 2019
Identifying tumour genetic markers is an essential task for biomedicine. In this thesis, we analyse a dataset of chromosomal rearrangements of cancer samples and present a methodology for extracting genetic markers from this dataset by using a Random ...
Pérez Arnal, Raquel Leandra
core   +1 more source

Perspectives of genomics for genetic conservation of livestock [PDF]

Genomics provides new opportunities for conservation genetics. Conservation genetics in livestock is based on estimating diversity by pedigree relatedness and managing diversity by choosing those animals that maximize genetic diversity.
Engelsma, K.A., Windig, J.J.
core   +3 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Development of a locus-specific, co-dominant SCAR marker for assisted-selection of the Sw-5 (Tospovirus resistance) gene cluster in a wide range of tomato accessions [PDF]

, 2010
The best levels of broad-spectrum Tospovirus resistance reported in tomatoes thus far are conferred by the Sw-5 locus. This locus contains at least five paralogues (denoted Sw-5a through Sw-5e), of which Sw-5b represents the actual resistance gene.
Boiteux, L.S., Dianese, E.C., Fonseca, M.E.N., Goldbach, R.W., Inoue-Nagata, A.K., Kormelink, R.J.M., Resende, R.O., de   +6 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source