Results 251 to 260 of about 5,022,316 (352)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Evaluating the Role of Genetic Markers in Predicting Oral Leukoplakia Malignancy Transformation.

J Pharm Bioallied Sci
Qurishi AA, Morsy MSM, Atout AM, Abzoah SE, Wadani MHM, Ghazwani NHA, Jafari SAM.   +6 more
europepmc   +1 more source

Potential Genetic Markers Associated with Environmental Adaptability in Herbivorous Livestock. [PDF]

Animals (Basel)
Liu X, Peng Y, Zhang X, Chen W, Chen Y, Wei L, Zhu Q, Khan MZ, Wang C.   +8 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Harnessing novel genetic markers for scald resistance from gene bank spring barley genotypes. [PDF]

BMC Plant Biol
Noe SM, Åstrand J, Zakieh M, Singh PK, Johansson E, Chawade A.   +5 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Integration of urine retinol-binding protein and genetic markers for early prediction of tacrolimus nephrotoxicity using machine learning. [PDF]

Transl Pediatr
Miao Y, Chen X, Xie P, Liang Y, Wei Y, Deng H, Huang Q, Qiu H, Li H, Zhou S, Liang H, Huang M, Li J, Gao X, Mo X.   +14 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

OMT and tensor SVD-based deep learning model for segmentation and predicting genetic markers of glioma: A multicenter study. [PDF]

Proc Natl Acad Sci U S A
Zhu Z, Wang H, Li T, Huang TM, Yang H, Tao Z, Tan ZH, Zhou J, Chen S, Ye M, Zhang Z, Li F, Liu D, Wang M, Lu J, Zhang W, Li X, Chen Q, Jiang Z, Chen F, Zhang X, Lin WW, Yau ST, Zhang B.   +23 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source