Results 251 to 260 of about 4,905,945 (358)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Polymorphisms of interleukin-8 and -18 genes and diabetic retinopathy

Open Life Sciences, 2010
Cilenšek Ines, Hercegovac Amela, Terzić Rifet, Petrovič Mojca, Petrovič Daniel   +4 more
doaj   +1 more source

Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome

, 1996
Xiaowen Liao, Isabelle Charlebois, Catherine Ouellet, Marie‐Josée Morency, Ken Dewar, Jeff Lightfoot, Jennifer Foster, Richard Siehnel, Herbert P. Schweizer, Joseph S. Lam, Robert E. W. Hancock, Roger C. Lévesque   +11 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

From bedside to bug side: clinical, haematological and genetic markers of antibiotic-resistant bacterial isolates from children admitted with sepsis in Kaduna State, Nigeria - a protocol for a cross-sectional study. [PDF]

BMJ Open
Musa S, Aliyu S, Abdullahi NB, Khalid HL, Salihu SK, Dahiru AU, Muhammad AA, Abdullahi K, Salisu S, Gumbi SA, Tanko ZL, Umaru HM, Bello-Manga H, Dogara LG, Musa A, Usman IK, Lawal UW, Cleary DW, Blair JMA.   +18 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Impact of genetic markers related to hyper-HDL cholesterol on the prevalence of myocardial infarction: a KoGES study. [PDF]

J Lipid Res
Lee SB, Hong KW, Park B, Jung DH.
europepmc   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Rheumatoid arthritis: a comprehensive overview of genetic markers, emerging therapies, and personalized medicine. [PDF]

Ann Med Surg (Lond)
Shakeel L, Shaukat A, Khaliq N, Kashif A, Mujeeb A, Adnan Z, Taj J, Akilimali A.   +7 more
europepmc   +1 more source