Results 271 to 280 of about 4,905,945 (358)

Genetic markers associated with ferroptosis in Alzheimer's disease. [PDF]

Front Aging Neurosci
Sun Y, Xiao Y, Tang Q, Chen W, Lin L.
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Genetic Markers as Predictors of Prognosis and Treatment Response in Patients with Oral Cancer: A Prospective Study.

J Pharm Bioallied Sci
Mohammed PR, Dash M, Pati S, Yaqoob A, Sanda S, Nelson A, Tiwari HD.   +6 more
europepmc   +1 more source

Multidimensional investigation of thyroid hormones and prostate cancer: insights from NHANES, Mendelian randomization, genetic markers, and bioinformatics analyses. [PDF]

Discov Oncol
Wu J, Chen S, Xu R, Chen Y, Guo J, Li J, Zeng X, Wang B, Zhu X.   +8 more
europepmc   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Genetic Markers of Spina Bifida in an Indian Cohort.

J Indian Assoc Pediatr Surg
Goel P, Sharma M, Kaushik H, Kumar S, Singh H, Jain V, Dhua AK, Yadav DK, Kumar N, Agarwala S.   +9 more
europepmc   +1 more source

Candidate Genetic Markers of Schizophrenia Based on Exome Sequencing Data and Its Relation to Immunological, Clinical, and Morphometric Changes in the Russian Population. [PDF]

Sovrem Tekhnologii Med
Rastorguev SM, Tsygankova SV, Kaidan MA, Ushakov VL, Malashenkova IK, Krynskiy SA, Ogurtsov DP, Hailov NA, Zakharova NV, Kostyuk GP.   +9 more
europepmc   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety. [PDF]

Nat Commun
Chen Z, Tang Y, Liu X, Li W, Hu Y, Hu B, Xu T, Zhang R, Xia L, Zhang JX, Xiao Z, Chen J, Feng Z, Zhou Y, He Q, Qiu J, Lei X, Chen H, Qin S, Feng T.   +19 more
europepmc   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source