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Genetic Predisposition to Neuroblastoma [PDF]
Children, 2018 Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis.
Erin K. Barr, Mark A. Applebaum
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Genetic Predisposition to Clonal Hematopoiesis [PDF]
HemaSphere, 2023 Pedro M. Quiros, George S. Vassiliou
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Genetic Predisposition to Hepatocellular Carcinoma
Metabolites, 2022 Liver preneoplastic and neoplastic lesions of the genetically susceptible F344 and resistant BN rats cluster, respectively, with human HCC with better (HCCB) and poorer prognosis (HCCP); therefore, they represent a valid model to study the molecular ...
Rosa M. Pascale +3 more
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Genetic Predisposition to Solid Pediatric Cancers
Frontiers in Oncology, 2020 Progresses over the past years have extensively improved our capacity to use genome-scale analyses—including high-density genotyping and exome and genome sequencing—to identify the genetic basis of pediatric tumors.
Mario Capasso +10 more
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Principles of genetic predisposition to malignancies [PDF]
Hereditary Cancer in Clinical Practice, 2008 It is estimated that around 30% of all malignancies are caused by a "high-risk" genetic predisposition [1]. This estimation is based on an evaluation of occurrence of disease among monozygotic twins. If one of them is affected with prostate (PC) or breast cancer (BC), then the probability of occurrence of this disease in the second sibling is 40% for ...
Dębniak Tadeusz, Lubiński Jan
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Genetic Predisposition to Infectious Disease [PDF]
Cureus, 2018 In contemporary medical practice, approaches to infectious disease management have been primarily rooted in a pathogen-centered model. However, host genetics also contribute significantly to infectious disease burden. The fast expansion of bioinformatics techniques and the popularization of the genome-wide association study (GWAS) in recent decades ...
N. Klebanov
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Genetic predisposition in nonalcoholic fatty liver disease [PDF]
Clinical and Molecular Hepatology, 2017 Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic ...
Silvia Sookoian, Carlos J. Pirola
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Genetic predisposition to cancer [PDF]
British Journal of Cancer, 1991 BAJ Ponder
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Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test?
International Journal of Molecular Sciences, 2023 Colorectal cancer is one of the most common tumors, and genetic predisposition is one of the key risk factors in the development of this malignancy. Lynch syndrome and familial adenomatous polyposis are the best-known genetic diseases associated with ...
F. Rebuzzi, P. Ulivi, G. Tedaldi
semanticscholar +1 more source
Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases [PDF]
Sci Rep 12, 19906 (2022), 2022 In a highly simplified view, a disease can be seen as the phenotype emerging from the interplay of genetic predisposition and fluctuating environmental stimuli. We formalize this situation in a minimal model, where a network (representing cellular regulation) serves as an interface between an input layer (representing environment) and an output layer ...
arxiv +1 more source