Results 1 to 10 of about 372,458 (325)

Genetic Predisposition to Neuroblastoma [PDF]

Children, 2018
Neuroblastoma is the most common solid tumor in children under the age of one. It displays remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with clinical and biologic features at diagnosis.
Erin K. Barr, Mark A. Applebaum
doaj   +3 more sources

The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities [PDF]

Nature Communications
Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization ...
Ana Luiza Arruda, Ozvan Bocher, Henry J. Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C. Wood, Ken Suzuki, Josep M. Mercader, Cassandra N. Spracklen, James B. Meigs, Marijana Vujkovic, George Davey Smith, Jerome I. Rotter, Benjamin F. Voight, Andrew P. Morris, Eleftheria Zeggini   +18 more
doaj   +2 more sources

Genetic predisposition in sarcomas: clinical implications and management [PDF]

EClinicalMedicine
Summary: Recent studies indicate up to 20% of sarcomas may be associated with predisposition genes, and this number will probably increase as genetic testing becomes more available.
Elizabeth A. Connolly, Kjetil Boye, Sylvie Bonvalot, Christian P. Kratz, Andreas Leithner, David Malkin, Christina Messiou, Aisha B. Miah, Pan Pantziarka, Beate Timmermann, Winette T.A. van der Graaf, David M. Thomas, Silvia Stacchiotti   +12 more
doaj   +2 more sources

Genetic Predisposition to Hepatocellular Carcinoma

Metabolites, 2022
Liver preneoplastic and neoplastic lesions of the genetically susceptible F344 and resistant BN rats cluster, respectively, with human HCC with better (HCCB) and poorer prognosis (HCCP); therefore, they represent a valid model to study the molecular ...
Rosa M. Pascale, Diego F. Calvisi, Francesco Feo, Maria M. Simile   +3 more
doaj   +3 more sources

Principles of genetic predisposition to malignancies [PDF]

Hereditary Cancer in Clinical Practice, 2008
It is estimated that around 30% of all malignancies are caused by a "high-risk" genetic predisposition [1]. This estimation is based on an evaluation of occurrence of disease among monozygotic twins. If one of them is affected with prostate (PC) or breast cancer (BC), then the probability of occurrence of this disease in the second sibling is 40% for ...
Dębniak Tadeusz, Lubiński Jan
doaj   +3 more sources

Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank [PDF]

Journal of Sport and Health Science
Background: It is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. We examined the joint associations of intensity-specific physical activity and genetic predisposition (based on ...
Matthew N. Ahmadi, Hamish D. Mundell, Greg T. Sutherland, Mark Hamer, Elina Sillanpää, Joanna M. Blodgett, Borja del Pozo Cruz, Emmanuel Stamatakis   +7 more
doaj   +2 more sources

Physical frailty, genetic predisposition, and incident arrhythmias [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Cross‐sectional evidence suggests a possible link between frailty and atrial fibrillation (AF). It remains unclear whether frailty and incident arrhythmias are longitudinally associated.
Yucong Zhang, Man Liu, Jiajun Li, Lei Ruan, Xiaofen Wu, Cuntai Zhang, Liangkai Chen   +6 more
doaj   +2 more sources

Greenness, Genetic Predisposition, and Tinnitus

Advanced Science
This study aimed to investigate the association between residential greenness and tinnitus and the potential interaction between greenness and genetic predisposition to tinnitus.
Lan‐Lai Yuan, Dan‐Kang Li, Yao‐Hua Tian, Yu Sun   +3 more
doaj   +3 more sources

Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism [PDF]

Heliyon
Background: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown.
Handan Tan, Zhenyu Zhong, Xiaojie Feng, Xiang Luo, Qingfeng Cao, Peizeng Yang   +5 more
doaj   +2 more sources

Associations of polyunsaturated fatty acids and genetic predisposition with cardiovascular risk among hypertensive adults. [PDF]

Front Nutr
Li J, Zhang Y, Liu S, Nong C, Chen Q, Zou Y, Peng Y, Chen H.   +7 more
europepmc   +3 more sources